Purpose: Mini-pig has been a great demand for basic and clinical research field due to easy handling, convenient size as well as its analytical and physiological similarity with human. It has been playing a huge role in several clinical research to imitate variety of diseases such as cardiovascular disease, diabetes, metabolic syndrome, bone disorders, skin diseases, and gastrointestinal diseases. It could be the most beneficial animal model for researching gastrointestinal diseases including gastric ulcer. Materials and Methods: Sus scrofa female mini-pig weighing around 30kg was used in this experiment. After a week of adaptation, animals were fasted for 48h with free access to the drinking water with subsequent endoscopic intra-gastric acetic acid injection. Mini-pigs were divided into 2 groups with 2 mini-pigs in each group. The process of gastric ulcer development was analyzed at the time of injection, on the 7th and on the14th day through endoscopy. Autopsy was done on the 14th day after drug injection followed by stomach tissue analysis. Results: Gastric ulcer was induced very efficiently in mini-pig animal with clearly visible signs of necrosis, inflammation and mineralization. The healing properties of famotidine were confirmed as disease symptoms were reduced significantly. Conclusion: We confirmed that mini-pig can be efficient and convenient species for gastric ulcer inducement with significant resemblance to human beings, and highly applicable to further effective preclinical experiments.
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