Hypertension is a common disease in clinical practice in many countries worldwide. There are currently about 1 billion people with hypertension, and it is estimated that by 2025, this number will reach 1.5 billion 1 . Hypertension is a deteriorative illness owing to its complications that damage target organs such as the heart, eyes, brain, and kidney, in which cardiovascular events are of particular concern. Many evidence show that arterial stiffness is an independent prognostic factor for predict-ting adverse cardiovascular outcomes in hypertensive patients 2 . The gold standard for determining arterial stiffness is to measure pulse wave velocity. Still, this method requires high-technology equipment, making it unavailable to be performed in some medical facilities, especially in the primary health care systems. Another method that correlates with the standard measurement is to evaluate by 24-hour ambulatory blood pressure monitoring. Although it is not a new method, it has adequacy of accessible opportunity, non-invasive feature, and does not require high-technical equipment. As a result, this
Background: Premature ventricular contraction (PVC) is a common arrhythmia that causes a large number of clinical symptoms, adversely impacts the quality of life, and can even initiate serious arrhythmias, such as ventricular tachycardia or ventricular fibrillation. The incidence of premature ventricular contraction is higher in hypertensive patients, particularly if concomitant left ventricular hypertrophy (LVH) is present. Objectives: This study was conducted on the characteristics of PVC in hypertensive patients with left ventricular hypertrophy and aimed to evaluate the effect of bisoprolol on PVC in Vietnamese patients with hypertension and LVH. Subjects and Methods: We conducted a study to determine how bisoprolol potency affected PVC management in the group with both high blood pressure and LVH. We selected a convenient sample of all patients who came to the Medical Examination Department at the Can Tho University of Medicine and Pharmacy Hospital and met sampling criteria with hypertension, LVH on echocardiography, and PVC on 12-leads electrocardiogram. Over 2 years, we collected 76 patients who satisfied the above conditions. Out of which, 50 patients were indicated for management with bisoprolol, and 26 patients were excluded from the study, including 7 patients with asthma and 19 patients who had simple PVC on a 24-hour Holter ECG. Data were analyzed with SPSS version Results: Fifty patients participated in the study, of whom 70% were female. It is clear that palpitation was the most prevalent symptom (66%), and 38% of patients had complicated PVC (Lown III-V). When treating PVC with bisoprolol, 50% of patients achieved the treatment goal with a decrease in the number of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs. After 4 weeks of treatment, bisoprolol decreased the number of PVCs, heart rate, and blood pressure while also easing PVC-related symptoms (p < 0.05). Conclusion: Low-dose bisoprolol effectively reduces the number of PVCs in hypertensive patients with LVH.
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