Acne and its harmful effects are considered reasons for the deterioration of the health, social, professional and psychological status of many people, especially in the age of sexual maturity and may lead to chronic skin abnormalities. The treatments used orally and parenterally cause hormonal disorders in addition to side effects on the digestive system. Topical treatment is one of the most important ways to treat acne and the skin abnormalities associated with it, which is characterized by lack of absorption through the skin, but modulating the local formula with nanotechnology and adding absorption stimuli increases the effectiveness of topical treatments. This study has advantage of designing and testing a new topical formula with standard kinetic and effective properties with the nano crystallization of spironolactone-ciprofloxacin-clindamycin-ascorbic acid to form the acne free formula to treat acne as no such design has been tested in laboratory studies. The study aims to increase the absorption, efficacy, and stability of topical treatment through the combination of nano crystalline crystals of spironolactone-ofloxacin-clindamycin-ascorbic acid and then test the resulting compound by diagnosing physical-chemical properties and measuring the absorptivity of the formula across the skin as well as measuring response and clinical safety. The study was conducted within three designs, which are laboratory, animal, and clinical. The laboratory study included diagnosing the physical and chemical properties of the formula by means of optical spectroscopy, pH measurement, peroxide, viscosity, and image processor technology in comparison to the traditional formula. The longitudinal and cross-sectional clinical study of the reviewers’ registry included finding anti-inflammatory efficacy and assessing therapeutic safety. The random sample method and the statistical analysis of the results were adopted, the results showed that the acne free formula had the ideal physical properties as in Table 1 and the absorption is higher than the commercial formula and has stability for a period about 36 months. The rate of active substance absorption was 8% compared to 5% in the commercial formula. Also, the clinical safety parameters are better than their comparison. As in Figure 1 From the general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula acne-free compared to the commercial formula
Skin allergy is a widespread skin problem at the level of different ages, and it occurs when an irritant comes into contact with the skin, and immune system believes it is under attack, so it overreacts and sends antibodies to help fight invaders. Oral corticosteroids are used to treat the symptoms caused by all kinds of allergic reactions. Long-term use may cause many side effects, such as white water on the eyes, brittleness, weak bones, and stomach ulcers and an increase in blood sugar (glucose) and growth retardation for children. Oral corticosteroids may also worsen high blood pressure. This study has the advantage of designing and testing new topical formulas with standard kinetics and efficacy properties by combining tocopherol with glycolate in addition to antihistamines (phenylephrine hydrochloride and diphenhydramine) to form a Noder formula for the treatment of hypersensitivity. The current study was formulated to manufacture the Noder formula which was submitted to extensive investigations and analyzes by four important models. The results showed that the Noder formula has the ideal physical properties and the absorption is higher than the commercial formula and it has stability for a period of 24 months. The therapeutic efficiency in reducing the degree of redness and sensitivity was 60% compared to 56% in the commercial formula, as well as the clinical safety parameters are better from its comparison of general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula Noder compared to the commercial formula.
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