Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks. Data on anthropometric parameters, food consumption, tumor necrosis factor alpha, high-sensitivity C-reactive protein, superoxide dismutase (SOD), glutathione peroxidase, catalase, total antioxidant capacity (TAC), and malondialdehyde (MDA) were assessed at the beginning and at the end of the study. Compared with the placebo group, CuEO increased SOD (149.17; 95% CI, [67.93, 230.42]), TAC (0.24; 95% CI, [0.09, 0.38]) and decreased MDA (−0.36; 95% CI, [−0.66, 0.06]),(p < 0.01). In within-group analysis, CuEO led to 13.3% decrease in MDA and 6.7% increase in TAC levels (p < 0.04). The results indicated that CuEO supplementation can improve some antioxidative indices, as SOD and TAC, while decreasing MDA in patients with MetS.
Metabolic syndrome (MetS) is a combination of interconnected disorders that puts a heavy burden on societies. This study investigated the impact of blueberry (BB) supplementation on components of MetS. A...
This study aimed to compare the efficacy of infliximab and etanercept in rheumatoid arthritis (RA) patients to help clinicians select the most effective treatment options. This was a cross sectional study conducted in Urmia, Iran, from March 21, 2017, to February 20, 2018. Data was collected by checklists from RA patients referred to the Rheumatology Clinic of Urmia Imam Khomeini Hospital who were receiving either infliximab or etanercept. Inclusion criteria were a diagnosis of RA according to the revised 2016 criteria of the American College of Rheumatology (ACR)/European League Against Rheumatism, aged over 18, consent to participate in the study, and poor response to other drugs. Both genders were included. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tender joint count (TJC), swollen joint count (SJC), and disease activity score (DAS) (28 scores) were analyzed before and after treatment. In a total of 44 eligible patients, 13 patients received infliximab and 31 received etanercept. The mean age was 53.92 ± 10.94 and 52.8 ± 64.13 years in the infliximab and etanercept groups, respectively. No significant differences were reported concerning ESR (p value = 0.97) or CRP (p value = 0.96), while a significant decrease in the infliximab group compared to the etanercept group was demonstrated in terms of DAS28 scores (p value = 0.028), global health (GH) 1 (p value = 0.005), SJC (p value = 0.008), and TJC (p value = 0.01). This study demonstrated a significant difference between the two groups in the DAS scores 28, SJC, TJC, and GH.
Metabolic syndrome (MetS) is the co-occurrence of several interconnected metabolic disorders and its prevalence is rising in the world. We hypothesized that blueberry (BB) feeding will have positive effects on components of MetS according to studies which used animal subjects. A systematic search for the studies in Science Direct, Embase, Cochrane and PubMed databases was done. The Studies which investigated effects of BB on components of MetS in animal models were included. Of 1030 potentially relevant studies, after investigation, 28 animal studies remained for further investigation. Of these, 1 study was conducted using pigs, one study using hamsters, 15 studies using mice and 11 studies using rats. 18 studies were eligible for the meta-analysis, and others were included in systematic review. The meta-analysis was done by Comprehensive Meta-analysis Software.The results of the meta-analysis demonstrated no significant effect of blueberry feeding on body weight [p = 0.65 CI95%: (-3.029, 1.892)]. However, a statistically significant improvement of systolic blood pressure [p < 0.001, CI95%: (-0.916, -0.283)], diastolic blood pressure[p = 0.01, CI95%: (-1.10, -0.13)], triglycerides[p = 0.01, CI95%: (-1.018, -0.109], total cholesterol [p < 0.001 CI95%: (-1.693, -0.782)], low density lipoprotein(LDL) [p = 0.008, CI95%: (-2.182, -0.334)], high density lipoprotein(HDL) [p = 0.02, CI95%: (0.077, 1.057)], blood glucose [p < 0.001, CI95%:( -1.638, -0.623)] and insulin level [p < 0.001, CI95%: (-1.711, -0.688)] was reported. Conclusion: this study showed that blueberry can be effective in ameliorating some components of metabolic syndrome in animal models. There is a need to conduct more studies on this subject in humans.
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread, long-term pain and multiple tender points revealed in physical examination. Previous studies about the relationship between serum vitamin D level and FM have reported paradoxical results. This cross-sectional study aimed to evaluate levels of vitamin D and its relationship with the severity of FM. Based on the American College of Rheumatology (ACS) criteria, 100 female patients with FM were enrolled in this study, and their serum vitamin D levels were screened. Vitamin D deficiency is defined as a level less than 12 ng/mL; insufficiency is defined as a level between 12-29 ng/mL; and sufficiency is a level equal to or greater than 30 ng/mL. Disease severity was evaluated by symptom severity scale (SSS) score and documented using designed questionnaires. Among the 100 female FM patients enrolled in this study, mean patient age was 35.60 years; 47% of them had vitamin D deficiency, 36% had vitamin D insufficiency, and only 17% had normal vitamin D serum levels. Vitamin D deficiency was reported among 50% of patients with an SSS score between 9 and 12, 49% of patients with an SSS score between 5 and 8, and 14.3% of patients with an SSS score between 1 and 4. There was no significant correlation between patient age and vitamin D level (p-value=0.12). Moreover, no significant correlation was found between patient age and SSS score (p-value=0.36). The current study demonstrated that there was no statistically significant relationship between FM disease activity and vitamin D serum level.
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