Beneficial effects of blueberry supplementation on the components of metabolic syndrome: a systematic review and meta-analysis

Azari, Hushyar; Morovati, Ashti; Gargari, BP; Sarbakhsh, Parvin

doi:10.1039/d1fo03715c

Cited by 3 publications

(1 citation statement)

References 112 publications

(289 reference statements)

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“…Meta-analysis provides notable advantages, including cost-effectiveness and feasibility compared to large-scale trials. This approach has gained extensive use in food science, particularly in investigating prevention and treatment strategies for cardiovascular diseases [20][21][22][23][24][25]. Furthermore, network pharmacology, as a methodology that reevaluates existing drugs, aids in discovering the potential efficacy and mechanisms of drugs already approved for treating new diseases, thus reducing the time and cost of developing new drugs [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Xia,

Yu,

Zhao

et al. 2023

Foods

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As a dietary supplement or functional food additive, vitamin D (VD) deficiency may impact extra-skeletal functions associated with metabolic syndrome (MetS) risk factors. However, the precise effects and mechanisms of VD supplementation on dyslipidemia and insulin resistance in MetS subjects remain controversial. Here, we investigate potential therapeutic targets, pathways and mechanisms of VD against MetS through a comprehensive strategy including meta-analysis, network pharmacology analysis, molecular docking, dynamics simulations, and quantum chemical calculations. Our results reveal that VD supplementation significantly reduces triglyceride levels, fasting glucose, and insulin concentrations in subjects, thereby improving insulin homeostasis to some extent. We theoretically identify 14 core MetS-associated targets. Notably, VD exhibits substantial interactions with three targets (PPARγ, FABP4, and HMGCR) in the PPAR signaling pathway, indicating that VD can modulate this pathway. Van der Waals forces predominantly stabilize the complexes formed between VD and the three targets. Nonetheless, to provide valuable insights for personalized MetS management, further research is necessary to confirm our findings, emphasizing the importance of exploring genetic variability in VD response. In conclusion, our study contributes insights into the mechanisms of VD in preventing and treating MetS through dietary supplementation, promoting the development of VD-based functional foods or nutritious diets.

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Section: Introductionmentioning

confidence: 99%

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Xia,

Yu,

Zhao

et al. 2023

Foods

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Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Gholami,

Maracy,

Paknahad

2024

Health Science Reports

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Metabolic syndrome (MetS) is the main general and clinical health challenge worldwide. Based on the National Cholesterol Education Program, if the person has three or more indices containing: elevated fasting blood sugar, high levels of triglycerides, hypertension, low levels of high‐density lipoprotein cholesterol, and central obesity, he suffers MetS.The Mediterranean‐Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay diet is a novel diet that with the specific aim of safeguarding cognitive function.Propolis is a resinous substance produced by bees from the combination of buds and secretions of plants with saliva and bee enzymes. After propolis supplementation, a significant reduction in fasting plasma glucose levels and lipid profiles has been observed.Considering the importance of chronic diseases like MetS on health, the role of the Mediterranean‐DASH Intervention for Neurodegenerative Delay (MIND) diet and propolis supplement that will improve blood sugar, blood lipid, anthropometric indicators, blood pressure, and cognitive function, and limited contradictory studies, we decided to conduct this study.This study, which is a randomized controlled clinical trial study, will be conducted on adults with MetS who will visit Hazrat Ali Health Center in Isfahan. Participants must provide informed consent before engaging in the study. Demographic data such as age, gender, and medical history will be recorded. Then, anthropometric indices, MetS indices, and cognitive function will be measured in all subjects.The study participants will be divided into three groups and will be controlled for 12 weeks. We will have a MIND diet + placebo group, a MIND diet + propolis supplement group, and a control group that will receive a microcrystalline cellulose placebo and usual dietary advice. At the end of the intervention, all indices will be assessed again.The data obtained in the study will be analyzed at descriptive and analytical levels by the statistical software SPSS26.The present study's protocol was approved by the Iranian Registry of Clinical Trials (www.irct.ir) on 3/28/2023 and a registration reference is IRCT20230105057054N1.

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Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation

Ahmadi

Jamialahmadi

Sahebkar

2022

Pharmacological Research

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Beneficial effects of blueberry supplementation on the components of metabolic syndrome: a systematic review and meta-analysis

Abstract: Metabolic syndrome (MetS) is a combination of interconnected disorders that puts a heavy burden on societies. This study investigated the impact of blueberry (BB) supplementation on components of MetS. A...

Cited by 3 publications

References 112 publications

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation

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