Abstract:Objectives: Despite the number of studies on neurometabolite changes in ADHD (Attention defi cit/ hyperactivity disorder), there is lack of evidence on neurometabolite associations with ADHD symptoms. Background: We aimed to fi nd the correlations of neurometabolites with ADHD symptoms. Methods: Twenty ADHD children were examined by means of 1 H-MRS. The spectra were taken from dorsolateral prefrontal cortex (DLPFC) and white matter behind DLPFC, bilaterally. Neurometabolites were correlated with ADHD-RS-IV (ADHD-Rating Scales IV), CPRS (Conners Parent rating Scale) and DPREMB (Daily Parent Rating of Evening and Morning Behavior) scores. Results: NAA/Cr (N-acetylaspartate/creatine) in the right DLPFC positively correlated with CPRS subscale IV learning problems and negatively correlated in the left white matter with DPREMB morning behavior subscale and ADHD-RS-IV score. Glx/Cr (glutamate + glutamine/creatine) positively correlated in the right white matter with ADHD-RS-IV and negatively correlated in the left white matter with DPREMB morning behavior subscale score. Cho/Cr (choline/creatine) in the left white matter negatively correlated with DPREMB morning behavior subscale and ADHD-RS-IV score. Conclusion: ADHD symptoms could result from different activities of the left-and right-hemisphere prefrontal circuits. In consequence to impulses to novel task searching the increased right prefrontal circuit activity could be mediated by different motivational control (Fig. 9, Ref. 73). Text in PDF www.elis.sk.
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