Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy

Abstract

Abstract:Objectives: Despite the number of studies on neurometabolite changes in ADHD (Attention defi cit/ hyperactivity disorder), there is lack of evidence on neurometabolite associations with ADHD symptoms. Background: We aimed to fi nd the correlations of neurometabolites with ADHD symptoms. Methods: Twenty ADHD children were examined by means of 1 H-MRS. The spectra were taken from dorsolateral prefrontal cortex (DLPFC) and white matter behind DLPFC, bilaterally. Neurometabolites were correlated with ADHD-RS-IV (ADHD-Rating Scales IV), CPRS (Conners Parent rating Scale) and DPREMB (Daily Parent Rating of Evening and Morning Behavior) scores. Results: NAA/Cr (N-acetylaspartate/creatine) in the right DLPFC positively correlated with CPRS subscale IV learning problems and negatively correlated in the left white matter with DPREMB morning behavior subscale and ADHD-RS-IV score. Glx/Cr (glutamate + glutamine/creatine) positively correlated in the right white matter with ADHD-RS-IV and negatively correlated in the left white matter with DPREMB morning behavior subscale score. Cho/Cr (choline/creatine) in the left white matter negatively correlated with DPREMB morning behavior subscale and ADHD-RS-IV score. Conclusion: ADHD symptoms could result from different activities of the left-and right-hemisphere prefrontal circuits. In consequence to impulses to novel task searching the increased right prefrontal circuit activity could be mediated by different motivational control (Fig. 9, Ref. 73). Text in PDF www.elis.sk.

Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties

“…Only one other study has examined the relationship between DLPFC glutamate concentration and subjective executive dysfunction symptom severity (Husarova et al, 2014a). Although this study found no correlation between left DLPFC glutamate and parentreported symptom severity, associations between executive symptom severity and other neurometabolites including N-acetylaspartate/creatine, Glx/creatine, and choline/creatine in the DLPFC or white matter behind the DLPFC were observed.…”

The Relationship between Neurocircuitry Dysfunctions and Attention Deficit Hyperactivity Disorder: A Review

“…In the study of the circuit, 1 H-magnetic resonance spectroscopy ( 1 H-MRS) demonstrates that N-acetylaspartate/creatine (NAA/Cr) value in right DLPFC is positively correlated with learning disabilities of ADHD, while NAA/Cr value in left DLPFC is negatively correlated with the morning behavior. It is indicated that the DLPFC neurometabolities between cerebral hemispheres of ADHD are correlated with different ADHD symptoms and each hemisphere controls its special executive functions [ 16 ]. ADHD participants had a significantly lower concentration of glutamate-glutamine-GABA (Glx), Cr, and NAA in corpus striatum and Cr in the DLPFC than control group.…”

Magnesium, iron, and zinc supplementation for the treatment of attention deficit hyperactivity disorder: A systematic review on the recent literature

“…The conclusive etiology of ADHD is still questionable. However, the role of dysfunction of the neuro circuitry within prefrontal cortex,[ 5 ] brain damage,[ 6 ] genetics,[ 7 ] infections, sugar, and deficiencies in certain vitamins, minerals,[ 8 ] and omega-3 fatty acids[ 9 ] is shown to some extent. Studies regarding the dietary intake have shown the harmful effects of food preservatives and additives.…”