In 2000 Chen introduced a two-parameter lifetime model and has reported only a few mathematical properties moments, quantile and generating functions, among others. In this article, we derive a power series expansion for newly introduced real upper parameter generalized integro-exponential function E p s (z) extending certain Milgram's findings. By our novel results we derive closed-form expressions for the moments, generating function, Rényi entropy and power series for the quantile function of the Chen distribution.
The present study encompasses the ethnomedicinal consumption of Corchorus depressus (L.) C.Chr. (C. depressus) for diabetes. Plant samples were subjected to LC-ESI-MS analyses. The n-hexane, methanolic and water extracts were screened for -glucosidase inhibition and in vivo anti-diabetic studies. Further, antioxidant (DPPH) and antiinflammatory study was performed via luminol-enhanced chemiluminescence assay. The identified compounds were docked against the target enzymes of diabetes. The n-hexane fraction (CD-J1) showed IC 50 of 8.4 ± 0.1 µg mL -1 against-glucosidase enzyme. The subfractions CD-12 and CD-13 of CD-J1 obtained after flash column chromatography displayed further reduced IC 50 values of 4.3 0.1 and 6.3 0.1, respectively, as compared with standard drug acarbose (IC 50 values of 37.5 ± 0.2 µg mL -1 ). Simultaneously, dereplication of the most active sub-fraction CD-12 by LC-ESI-MS led to the identification of strophanthidin and some other active metabolites responsible for anti-diabetic activity. Molecular docking of strophanthidin with -glucosidase and -amylase revealed high affinity for these target enzymes.
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