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Lysine acetylation is a common reversible post‐translational modification of proteins that plays a key role in regulating gene expression. Nuclear receptors (NRs) include ligand‐inducible transcription factors and orphan receptors for which the ligand is undetermined, which together regulate the expression of genes involved in development, metabolism, homeostasis, reproduction and human diseases including cancer. Since the original finding that the ERα, AR and HNF4 are acetylated, we now understand that the vast majority of NRs are acetylated and that this modification has profound effects on NR function. Acetylation sites are often conserved and involve both ordered and disordered regions of NRs. The acetylated residues function as part of an intramolecular signalling platform intersecting phosphorylation, methylation and other modifications. Acetylation of NR has been shown to impact recruitment into chromatin, co‐repressor and coactivator complex formation, sensitivity and specificity of regulation by ligand and ligand antagonists, DNA binding, subcellular distribution and transcriptional activity. A growing body of evidence in mice indicates a vital role for NR acetylation in metabolism. Additionally, mutations of the NR acetylation site occur in human disease. This review focuses on the role of NR acetylation in coordinating signalling in normal physiology and disease.

Coronavirus pandemic had not only affected the physical health of people but also the mental health of people globally. It has developed a fear in the minds of people regarding their selves as well as their loved ones. The essential change in the lifestyles of people and the need for social distancing has stopped the normal activities of people which caused mental disturbance among them. The present quantitative survey-based research has been led to know the impression of COVID 19 on the mental pressure of the students regarding their academic progress. The hypothesis were developed from which one was a null hypothesis;  H1, was to find that whether there is a positive relationship between mental stress and COVID and third, H2, was to find whether there is any negative relationship between mental stress and academic progress. Both, H1 and H2, were accepted through conducting quantitative research by circulating an online survey that consists of 14 close-ended questions regarding the 2 research questions made. Respondents were taken from 5 universities of Karachi, Iqra university, Jinnah university for women, NED university of Engineering and Technology, University of Karach, and ZABIST university.  The samples was consist of   90 students (54) were females and (36) were male selected by simple random sampling. The statistical method used to analyze the results was the simple percentage method as it clearly defines what percentages of the students were affected by COVID and how it impacted their mental pressure. It was found that there was a positive relationship of COVID on mental pressure that means the complex spread of COVID 19, higher the mental pressure and there was a negative relationship between COVID 19 and academic performance that means that high mental pressure was the cause of the lower performance.

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India being a developing economy is one of the emerging markets in the world. But an obstacle that still stands in its way of development is the scarcity of inancial/monetary resources required for sustainable investments. The giants of Micro inance in India are known to be charging high rates and the smaller players follow in their footsteps. For such regions, Interest-free micro inance is what is needed to uplift the minority and take them out of the fangs of poverty. Interest-free micro inance and its implementation can prove to be very useful in eradicating poverty and providing sustainable development of micro-enterprises and the expansion of inancial inclusion. Thus, the aim of this study is to examine the prospects of Islamic micro inance in India. The quantitative method is employed, and primary data is collected through a questionnaire. The probability sampling method is used. Out of 500 questionnaires disbursed, 303 are received. The result of the questionnaire shows that majority of the public believes Islamic Micro inance Institions (IMFIs) will aid the poor inancially, poverty will be alleviated, it will be bene icial to the society, and will help micro SMEs become more developed. Similarly, majority of the respondents also agreed to IMFIs being ethical, meant for all religions, catering to the needs of the society and help to extend loans without collaterals. This re lects that Islamic Micro inance holds great potential and prospects and will be widely accepted by the public and also the Indian market. Policymakers should consider IMFIs, establish guidelines and promulgate them as this can pave way to a inancially more stable India. The limitation of the study is that the outreach was among people with access to the internet. Therefore, perception of those in rural areas, people with no internet and education could not be included. Hence, future research will ful ill this lacuna.

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