Osteoarthritis (OA) is the most common joint disease that can cause pain and disability in adults. The main pathological characteristic of OA is cartilage degeneration, which is caused by chondrocyte apoptosis, cartilage matrix degradation, and inflammatory factor destruction. The current treatment for patients with OA focuses on delaying its progression, such as oral anti-inflammatory analgesics or injection of sodium gluconate into the joint cavity. Primary cilia are an important structure involved in cellular signal transduction. Thus, they are very sensitive to mechanical and physicochemical stimuli. It is reported that the primary cilia may play an important role in the development of OA. Here, we review the correlation between the morphology (location, length, incidence, and orientation) of chondrocyte primary cilia and OA and summarize the relevant signaling pathways in chondrocytes that could regulate the OA process through primary cilia, including Hedgehog, Wnt, and inflammation-related signaling pathways. These data provide new ideas for OA treatment.
Background
The aim of this study was to identify the key genes that changed after weight loss intervention in patients with osteoarthritis (OA) at different ages by identifying differentially expressed genes (DEGs).
Methods
GSE114007 and GSE158850 gene expression data were downloaded from Gene Expression Omnibus (GEO) database, DEGs were found using R software, and overlapping DEGs were obtained. The results were screened and validated by receiver operating characteristic (ROC) curve and boxplot. The immune cell infiltration and Gene Set Enrichment Analysis (GSEA) of the two genes were analyzed.
Results
There were two overlapping DEGs between OA dataset with the young group of obese men who had weight loss intervention, after screening, MAFB was remaining. There were two overlapping DEGS with the aged group, and the remaining one was BPGM. The results of immunological cell infiltration showed that these two genes were associated with macrophages. Enrichment analysis showed that MAFB was associated with the “Linoleic acid metabolism” pathway in both datasets.
Conclusion
MAFB and BPGM may be the therapeutic targets for obese patients with OA, and may be the indicators for evaluating the effectiveness of intervention.
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