Scarring
is caused by excessive medical treatment in the tissue
remodeling stage; hence, the need for medication is not constant throughout
the stage of burn recovery. In this study, we construct a nano self-adaption
release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8
(ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound
for the treatment of burns. The release of Cur within 48 h in the
media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%,
which could realize antibacterial functions in the inflammation stage,
wound healing in the tissue proliferation/formation stage, and prevention
of excessive fibroblast development and aberrant extracellular matrix
deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA
has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system
with antibacterial wound-healing properties and prevents scarring
functional based on the ZIF8-HA nano-vehicle, which opens a new way
for the clinical application of curcumin for burn healing.
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