The combined PDT not only shows high cure rate for skin cancers but also decreases the dose of the pro-toxic HPD and significantly shortens the photosensitive period, from which the patients are able to benefit.

As the world's aging population grows, fall is becoming a major problem in public health. It is one of the most vital risk to the elderly. Many technology based fall detection systems have been developed in recent years with hardware ranging from wearable devices to ambience sensors and video cameras. Several machine learning based fall detection classifiers have been developed to process sensor data with various degrees of success. In this paper, we present a fall detection system using infrared array sensors with several deep learning methods, including long-short-term-memory and gated recurrent unit models. Evaluated with fall data collected in two different sets of configurations, we show that our approach gives significant improvement over existing works using the same infrared array sensor.

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The geographically weighted regression (GWR) has been widely applied to many practical fields for exploring spatial non-stationarity of a regression relationship. However, this method is inherently not robust to outliers due to the least squares criterion in the process of estimation. Outliers commonly exist in data sets and may lead to a distorted estimate of the underlying regression relationship. Using the least absolute deviation criterion, we propose two robust scenarios of the GWR approaches to handle outliers. One is based on the basic GWR and the other is based on the local linear GWR (LGWR). The proposed methods can automatically reduce the impact of outliers on the estimates of the regression coefficients and can be easily implemented with modern computer software for dealing with the linear programming problems. We then conduct simulations to assess the performance of the proposed methods and the results demonstrate that the methods are quite robust to outliers and can retrieve the underlying coefficient surfaces satisfactorily even though the data are seriously contaminated or contain severe outliers.

Tuberculosis (TB) is an infectious disease that threatens human safety. Mainland China is an area with a high incidence of tuberculosis, and the task of tuberculosis prevention and treatment is arduous. This paper aims to study the impact of seven influencing factors and spatial–temporal distribution of the relative risk (RR) of tuberculosis in mainland China using the spatial–temporal distribution model and INLA algorithm. The relative risks and confidence intervals (CI) corresponding to average relative humidity, monthly average precipitation, monthly average sunshine duration and monthly per capita GDP were 1.018 (95% CI 1.001–1.034), 1.014 (95% CI 1.006–1.023), 1.026 (95% CI 1.014–1.039) and 1.025 (95% CI 1.011–1.040). The relative risk for average temperature and pressure were 0.956 (95% CI 0.942–0.969) and 0.767 (95% CI 0.664–0.875). Spatially, the two provinces with the highest relative risks are Xinjiang and Guizhou, and the remaining provinces with higher relative risks were mostly concentrated in the Northwest and South China regions. Temporally, the relative risk decreased year by year from 2013 to 2015. It was higher from February to May each year and was most significant in March. It decreased from June to December. Average relative humidity, monthly average precipitation, monthly average sunshine duration and monthly per capita GDP had positive effects on the relative risk of tuberculosis. The average temperature and pressure had negative effects. The average wind speed had no significant effect. Mainland China should adapt measures to local conditions and develop tuberculosis prevention and control strategies based on the characteristics of different regions and time.

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