Integrated writing tasks that involve different language modalities such as reading and listening have increasingly been used as means to assess academic writing. Thus, there is a need for understanding how test-takers coordinate different skills to complete these tasks. This study explored second language writers' strategy use and its relationship to test performance on an integrated reading-listeningwriting test task using a structural equation modeling approach. The results reveal that integrated writing strategy use was a multifaceted construct consisting of three factors: self-regulatory strategy use (SELFS), discourse synthesis strategy use (DSS), and "test-wiseness" strategy use (TWS). SELFS had an executive control over other types of strategy use. DSS had a direct, positive impact on test performance, and TWS had a direct, negative impact on test performance. The study suggests that the task requires not only comprehension and production abilities, but also regulation skills for managing reading, listening, and writing interactions. The findings provide insight into the nature of integrated reading-listening-writing tasks and contribute to validity arguments for the test. The study has implications for second language academic writing assessment, learning, and instruction.
Objectives: SMAD3 is pivotal in the biology functions of various tumors. This study is aiming to study the relationship among SMAD3, long noncoding RNAs (lncRNAs) OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1), and miR-143-3p, and their effects on cervical cancer.Methods: In our research, real-time polymerase chain reaction and western blot assay were conducted to detect the expression level of messenger RNA and protein in tumor tissues and cells. Transfection of lncRNA OIP5-AS1, miR-143-3p, or SMAD3 was performed to investigate their potential effects on the function of cell as well as the relationship among them in cervical cell lines via 3-(4,5-dimethylthiazolyl-2)-2,5diphenyltetrazolium bromide) together with transwell assays or dual-luciferase reporter assay respectively.Results: SMAD3, lncRNA OIP5-AS1 expression is significantly enhanced in cervical cancer tissues and cell lines, but miR-143-3p was inhibited. LncRNA OIP5-AS1 is demonstrated to mediate the physiological process of cervical cancer cells. Moreover, silencing SMAD3 via siRNA suppressed cell number, viability, migration and invasion, whereas overexpression of OIP5-AS1 promoted these abilities. Furthermore, lncRNA OIP5-AS1 exert its function via sponging miR-143-3p to regulate SMAD3 expression.Conclusions: LncRNA OIP5-AS1 promoted SMAD3 expression via mediating miR-143-3p to promote migration and invasion of cervical cancer cells.
K E Y W O R D Scervical cancer, lncRNA OIP5-AS1, migration, miR-143-3p, SMAD3
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