The metabolic syndrome and the aggregation of its components were significantly associated with macro- and microvascular complications in Type 2 DM patients.

Diabetic complications are frequent among out patients referring to general hospitals. Almost all patients presented at least one risk factor for cardiovascular disease, justifying the efforts for identification and adequate control.

No abstract

No abstract

No abstract

Diabetic retinopathy is one of the leading causes of blindness in working-age individuals. Diabetic patients with proteinuria or those on dialysis usually present severe forms of diabetic retinopathy, but the association of diabetic retinopathy with early stages of diabetic nephropathy has not been entirely established. A cross-sectional study was conducted on 1214 type 2 diabetic patients to determine whether microalbuminuria is associated with proliferative diabetic retinopathy in these patients. Patients were evaluated by direct and indirect ophthalmoscopy and grouped according to the presence or absence of proliferative diabetic retinopathy. The agreement of diabetic retinopathy classification performed by ophthalmoscopy and by stereoscopic color fundus photographs was 95.1% (kappa = 0.735; P < 0.001). Demographic information, smoking history, anthropometric and blood pressure measurements, glycemic and lipid profile, and urinary albumin were evaluated. On multiple regression analysis, diabetic nephropathy (OR = 5.18, 95% CI = 2.91-9.22, P < 0.001), insulin use (OR = 2.52, 95% CI = 1.47-4.31, P = 0.001) and diabetes duration (OR = 1.04, 95% CI = 1.01-1.07, P = 0.011) were positively associated with proliferative diabetic retinopathy, and body mass index (OR = 0.90, 95% CI = 0.86-0.96, P < 0.001) was negatively associated with it. When patients with macroalbuminuria and on dialysis were excluded, microalbuminuria (OR = 3.3, 95% CI = 1.56-6.98, P = 0.002) remained associated with proliferative diabetic retinopathy. Therefore, type 2 diabetic patients with proliferative diabetic retinopathy more often presented renal involvement, including urinary albumin excretion within the microalbuminuria range. Therefore, all patients with proliferative diabetic retinopathy should undergo an evaluation of renal function including urinary albumin measurements.

Purposes: The aim of the study was to investigate the prevalence of peripheral diabetic neuropathy (PDN) and associated characteristics among type 2 diabetic mellitus (DM2) patients in Passo Fundo, a city on Southern Brazil. Basic procedures: A cross-sectional study was conducted with 340 patients with type 2 diabetes mellitus. Tests were performed to evaluate vibration (tuning fork), light touch (10-g monofilament), temperature, and pain (pinprick) sensations, as well as ankle reflexes and heel walking. The condition was classified as peripheral diabetic neuropathy when results in at least three of these tests were negative. The electrically induced Hoffmann reflex test was performed in a group of patients to define the criterion standard used in the assessment of clinical examination sensibility in the diagnosis of neuropathy. Sensitivity was 83%, specificity, 91%, positive predictive value, 63%, and negative predictive value, 90%. The monofilament, pinprick and deep tendon reflex were the most accurate tests in the diagnosis of neuropathy. Main findings: Seventy-five patients (22.1%) had peripheral diabetic neuropathy, nephropathy in 29.5% and retinopathy in 28.8%. Conclusions: Logistic regression revealed that only duration of diabetes, creatinine and glycated hemoglobin concentrations were significantly associated with neuropathy. RESUMOPrevalência e Características da Polineuropatia Diabética em Passo Fundo, Sul do Brasil. Propósito: O objetivo deste estudo foi investigar a prevalência da neuropatia diabética periférica (NDP) e características associadas entre pacientes com diabetes melito tipo 2 (DM2) na cidade de Passo Fundo, sul do Brasil. Procedimentos básicos: Um estudo de corte foi realizado com 340 pacientes portadores de DM2. Testes foram conduzidos a fim de avaliar sensações de vibração (diapasão), de toque leve (monofilamento 10 g), de temperatura e de dor (agulha), bem como reflexos do tornozelo e caminhar com os calcanhares. A condição foi classificada como NDP quando os resultados em pelo menos três desses testes foram negativos. O teste reflexo de Hoffman induzido eletricamente foi conduzido em um grupo de pacientes a fim de determinar o critério padrão usado na avaliação da sensibilidade do exame clínico no diagnóstico de neuropatia. A sensibilidade foi de 83%, especificidade, 91%, valor preditivo positivo, 63% e valor preditivo negativo, 90%. O teste do monofilamento, a dor e o reflexo do tendão foram os mais precisos no diagnóstico de neuropatia. Principais achado: Setenta e cinco pacientes (22,1%) foram diagnosticados com NDP, nefropatia em 29,5% e retinopatia em 28,8%. Conclusões: Regressão logística revelou que somente a duração do diabetes e as concentrações de creatinina e hemoglobina glicada foram significativamente associados à neuropatia.

No abstract