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Vitamin E, or more specifically a-, @-, y-, and &tocopherols, functions in the body in some manner which is still unknown. The current working hypothesis is that vitamin E acts primarily and specifically through some enzyme system and, secondarily, in a non-specific manner as a physiological antioxidant. The general methods for approaching this problem fall logically into three main divisions: first, are the studies of the changes in enzyme systems which result from vitamin E deficiency; second, and very closely allied, are studies of changes in enzyme systems in which the tocopherols

As previously stated, the administration of testosterone to many animals including man and the Rhesus monkey, results in an increased urinary excretion of androgens and 17-ketosteroids. In contradistinction to this we noted no increase in either of these substances in the urine of treated Cebus monkeys. This finding parallels those of Dingemanse and Tyslowitz,lo Paschkis et aZ.,ll who found no increase in 10 Dingemanse, E., and Tyslowitz, R., Endocrinology, 1941, 28, 450.--_ _ the urine of dogs similarly treated. In dogsll and man12 increased urinary estrogenic activity has been shown after testosterone treatment. Our results would suggest that in the Cebus monkey as in man and the dog, testosterone can be converted to estrogens, but further work is necessary to elucidate this point.