Green-light emitting illuminant and green pearls that are currently being used for pyrotechnics are mainly composed of barium carbonate and polyvinyl chloride (PVC), which lead inevitably to the substantial generation of abundant harmful products for environmental pollution. There is thus considerable scope for the development of a novel emitting illuminant with an improved "green" composition instead of compositions incorporating barium based oxidants and polyvinyl chloride for environmental protection. For this purpose, a new composition composed of boron carbide, potassium perchlorate, and guanidine nitrate with a suitable burning rate of 5~15 mm/s required for fireworks, the high luminous intensity of 34665 Cd and spectral purity of 67.1 % at a primary wavelength of 562 nm was developed. Notably, PM10 data demonstrated that the new composition generated less than half the amount of the smoke relative to the original one. More importantly, all of the safety parameters of this new formulation meet well with the standards' requirements, i. e., a remarkable low sensitivity to friction (0 %) and impact (8 %), relative stability to electric discharge (374.4 mJ), flame (14.0 cm) and heating (unburned, unexploded at 75°C for 48 h), as well as a high ignition temperature of 504.0°C and a low moisture absorption rate (0.66 %). Taken together, the new emitting illuminant developed herein showed great potential to be used for fireworks and signal flare in both military and civilian applications.
Colorectal cancer (CRC) is one of the most common malignancies among human, which is often connected with increased incidence and mortality rate. DnaJ Heat Shock Protein Family (Hsp40) Member C2 (DNAJC2) is an epigenetic factor, which is involved in a number of cytological functions, such as transcriptional regulation and ubiquitination. A number of studies reveal that DNAJC2 is closely associated with several tumors. However, the function and mechanism of DNAJC2 in CRC remains to be elucidated. In the present study, the expression of DNAJC2 was detected in CRC tissues and adjacent normal tissues. The results indicated that DNAJC2 was increased in CRC tissues and the expression level of DNAJC2 was significantly associated with tumor size. Cell function was detected via Cell Counting Kit-8, 5-ethynyl-2'-deoxyuridine, colony formation assays and flow cytometry by upregulating or knocking down of DNAJC2. Overexpression of DNAJC2 could accelerate cell proliferation while suppression of DNAJC2 decreased cell proliferation, possibly via the regulation of cell cycle regulation in vitro. It was also found that the function of DNAJC2 was reversely regulated by miR-672-3p, causing the promoting of cell proliferation through the activation of AKT/P21 signal pathway in CRC cells. These results suggested that DNAJC2 is a tumor-regulated protein in the progression of CRC and may represent a novel target for CRC detection and therapy.
The Oxygen reduction reaction (ORR) plays an important role in fuel cells, but the synthesis of efficient and low-cost catalysts remains challenging. We report the synthesis of ultra-small Mo 2 C nanoparticles with an average size of 1.5 nm embedded in a N-doped holey carbon (NHC) matrix by employing selfassembled macrocycle cucurbit[6]uril (CB[6]) and melamine as carbon precursors. The interaction between Mo precursors and CB[6] effectively prevented the aggregation of Mo 2 C NPs during the pyrolysis procedure. Besides, the holey structural carbon has a larger electrocatalytic activity area and improves mass transfer efficiency and charge transfer rate. The NHC features abundant defective sites and thus effective anchoring and electronic regulation for Mo 2 C nanoparticles. The electrochemical oxygen reduction activity of Mo 2 C/NHC is comparable to that of noble metal Pt/C benchmark catalyst with an initial potential, half-wave potential and limiting current density of 0.95 V, 0.84 V and 5.0 mA cm À 2 , respectively. Mo 2 C/NHC shows a good long-term durability during 25 h chronoamperometry.
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