Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis. The aim of the present study is to investigate whether SCU treatment attenuates isoprenaline-induced myocardial fibrosis and the mechanisms of its action. Rats were injected subcutaneously with isoprenaline (Iso) to induce myocardial fibrosis and rats in the SCU treatment groups were intraperitoneally infused with SCU (10 mg·kg
15612(CD31), and the Notch signalling proteins (Notch1, Jagged1 and Hes1) were examined. The administration of SCU resulted in a significant improvement in cardiac function and decrease in the cardiac weight indices; reduced fibrous tissue proliferation; reduced levels of type I and III collagen; increased microvascular density; and decreased expression of α-smooth muscle actin and increased expression of CD31, Notch1, Jagged1 and Hes1 in isoprenaline-induced myocardial fibrosis in rats. Our results suggest that SCU prevents isoprenaline-induced myocardial fibrosis via inhibition of cardiac endothelial-mesenchymal transition potentially, which may be associated with the Notch pathway.
Mechanical roughening reportedly had a weakening effect on bond strength. Therefore, the purpose of this study was to evaluate the effect of an alternative surface roughening method, namely oxygen plasma treatment, on the tensile bond strength between denture base resin and soft liner. The soft liner used in this study was Soft Reverse, whilst the denture base material was Zi Ran. Three groups of specimens were prepared, comprising untreated specimens and oxygen plasma-treated specimens with exposure to air for 1 day and 2 days. All specimens were subjected to surface composition analysis and tensile bond strength testing. All data were analyzed using one-way ANOVA, and their mean values were compared using Tukey's HSD test (p<0.01). Highest tensile bond strength was observed in the 1-day exposure group (5.2 MPa), whilst the lowest in the control group of untreated specimens (2.8 MPa). Hence, results of this study clearly indicated that oxygen plasma treatment was effective in enhancing tensile bond strength.
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