a b s t r a c tSulfur (S VI ) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S VI )-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S VI ) based drugs against the numerous death-causing diseases.

A Heck-Matsuda process for the synthesis of the otherwise difficult to access compounds, β-arylethenesulfonyl fluorides, is described. Ethenesulfonyl fluoride (i.e., vinylsulfonyl fluoride, or ESF) undergoes β-arylation with stable and readily prepared arenediazonium tetrafluoroborates in the presence of the catalyst palladium(II) acetate to afford the E-isomer sulfonyl analogues of cinnamoyl fluoride in 43–97% yield. The β-arylethenesulfonyl fluorides are found to be selectively addressable bis-electrophiles for sulfur(VI) fluoride exchange (SuFEx) click chemistry, in which either the alkenyl moiety or the sulfonyl fluoride group can be the exclusive site of nucleophilic attack under defined conditions, making these rather simple cores attractive for covalent drug discovery.

a b s t r a c tAt present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. This review describes the recent advances in the synthesis of chlorine containing heterocyclic compounds as diverse biological agents and drugs in the pharmaceutical industries for the inspiration of the discovery and development of more potent and effective chlorinated drugs against numerous death-causing diseases.

The development of new and highly efficient strategies for the rapid construction of complicated molecular structures has huge implications and remains a preeminent goal in present day synthetic chemistry.

Tailoring of the chemical structure is an effective method to tune the aggregation and optoelectronic properties of organic photovoltaic materials to boost the performance of organic solar cells (OSCs). Here, four non-fullerene electron acceptor materials, namely, BTP-4F-C8-16, BTP-4F-C7-16, BTP-4F-C6-16, and BTP-4F-C5-16, with different lengths of alkyl chain on the bithiophene units were synthesized, and the impact of chain length on the intermolecular stacking, nanoscale phase separation with polymer donors, optoelectronic properties, and device performance were investigated. Molecular dynamics simulations and experimental exploration show that reducing the chain length from n-octyl (C8) to n-pentyl (C5) can enhance the molecular planarity, shorten the π−π stacking distance, and improve the electron mobility, consequently leading to enhanced structural order, charge mobility, and appropriate phase separation in the blend with PM6, contributing to the achievement of the best power conversion efficiency of 18.20% with a V OC of 0.844 V, a fill factor of 77.68%, and a J SC of 27.78 mA cm −2 , which is one of the highest efficiencies of single-junction binary OSCs reported in the literature so far.

A palladium-catalyzed fluorosulfonylvinylation reaction of organic iodides is described. Catalytic Pd(OAc)2 with stoichiometric silver(I) trifluoroacetate enables the coupling process between an (hetero)aryl or alkenyl iodide and ethenesulfonyl fluoride (ESF, 1). The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access compounds in up to 99% yields, including the unprecedented 2-heteroarylethenesulfonyl fluorides, and 1,3-dienylsulfonyl fluorides.

In recent years,v isible-light-induced C À H bond functionalization has become an emerging field at the forefront of organic chemistry.I nag eneral sense,t hese approaches rely on the capability of metal complexes ando rganic dyes to convert visible light into chemical energy by engaging in single-electron transfer with organic substrates,t husg enerating reactivei ntermediates.T hisr eview covers most of the strategies involving visible light-induced benzylic and non-benzylic

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