Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

Abstract

a b s t r a c tSulfur (S VI ) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S VI )-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S VI ) based drugs against the numerous death-causing diseases.

Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5‐Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease

“…In vitro inhibition against AChE was performed for all synthesized 2,4,5‐trisubstituted imidazoles 3a – 3m . Eserine was used as control in this assay . The results were summarized in Table , which illustrates that 3m , 3k , and 3e are the more potent AChE inhibitor as compared to the rest of synthesized compounds that showed moderate activity.…”

“…Eserine was used as control in this assay. [43][44][45] The results were summarized in Table 3, which illustrates that 3m, 3k, and 3e are the more potent AChE inhibitor as compared to the rest of synthesized compounds that showed moderate activity. Compound 3m bearing one ethoxy and one hydroxy group on phenyl moiety at position 2 of imidazole nucleus proved the most active compound with IC 50 value of 102.18 � 0.12 μM.…”

Synthetic Approach to Fused Azasultams with 1,2,4-Thiadiazepine Framework

“…The reaction progress was monitored by TLC on Merck 60 F 254 silica gel plates using hexanes-EtOAc as the eluent. 1…”

“…Sulfonamides have gained a great deal of consideration owing to a wide range of their bioactive properties in medicinal 1 and agricultural 2 areas. The historical journey of sulfonamides as a privileged structure in drug design began when the first synthetic antibiotic Prontosil was discovered in the 1930s.…”

Nickel-Catalyzed Inter- and Intramolecular Carbon-Sulfur Bond Metathesis by Reversible Arylation

“…pharmaceuticals, [2][3][4] materials, [5] photoinitiators, [6] and fragrances. [7] Thus,t he manipulation of C(sp 2 )ÀSb onds has recently become an active research area in transition-metal catalysis.…”