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2019) Clinical significance of CD8 + T cell immunoreceptor with Ig and ITIM domains + in locally advanced gastric cancer treated with SOX regimen after D2 gastrectomy, OncoImmunology, 8:6, e1593807, ABSTRACTGastric cancer (GC) development and progression is significantly associated with tumour immune escape. T cell immunoreceptor with Ig and ITIM domains (TIGIT) inhibits T-cell responses and is associated with human cancers and T cell exhaustion phenotypes, but its role in cancers remains unclear. TIGIT and programmed cell death protein (PD)-1 levels were detected in 441 human GC specimens using histochemistry. We used flow cytometry to evaluate percentage of TIGIT + constituting CD8 + T cells of 23 patients with GC who underwent D2 gastrectomy and the S-1 plus oxaliplatin (SOX) regimen. We investigated the influence of SOX regimen and TIGIT functional antibody on CD8 tumour-infiltrating lymphocytes (TILs). Results showed that PD-1 and TIGIT were significantly over expressed in GC and predicted poorer outcome, agreeing with bioinformatics analysis. Significantly reduced percentages of CD8 + TIGIT + cells were observed in patients after D2 gastrectomy (pre-vs post-surgery, 38 ± 8.7% vs. 26.7% ± 5.2%, p < 0.0001). TIGIT expression on CD8 + T cells was modulated by chemotherapeutics (pre-and post-chemotherapy, 31.3 ± 9% vs. 25.1 ± 4.5%, respectively, p = 0.0047) and higher TIGIT expression in post-chemotherapy group was associated with relapsed GC (p = 0.036). In vitro experiments revealed increased CD8 + TIL proliferation and interferon (IFN)-γ production following SOX regimen and TIGIT functional antibody treatments. In conclusion, TIGIT contributes to CD8 + TILs immune dysfunction in patients with GC. Combination of anti-TIGIT therapy and chemotherapy could be considered a therapy for GC. ARTICLE HISTORY

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Near threshold fatigue crack growth under mixed-mode loading and elastic plane-strain conditions has been studied in 316 stainless steel in laboratory air at room temperature. Particular emphasis was placed on the influence of the mode I1 component. Crack growth from the starter crack, although initially coplanar, branches to be perpendicular to the maximum normal stress. However the threshold for the branched crack growth is controlled not only by mode I displacement, but also by the mode I1 component. Upper and lower bound curves are obtained for the threshold condition and discussed in terms of crack tip reversed plastic deformation. crack surface rubbing and oxide-induced closure. A theoretical method for predicting the lower bound curve is proposed and compared with the maximum normal stress and strain energy density criteria. The new theory shows the best agreement with experimental results, giving a safe prediction for design purposes.

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Highly filled wood flour/recycled high density polyethylene (WF/RHDPE) composites were directly prepared by in situ reactive extrusion using a twin-screw/single-screw extruder system. The effects of dicumyl peroxide (DCP) content on extrusion pressure, rheological behavior, mechanical properties, fractured surface morphology of the composites, and melting temperature of RHDPE in the composites were investigated. The extrusion pressure and torque of WF/RHDPE composite melt increased with DCP content. Mechanical property tests and scanning electron microscopy analysis results confirmed that the interfacial interaction of the composites was improved by in situ reaction. The composites show lower melting peak temperature (T m ) than RHDPE. The Polym Sci 124: 5247-5253, 2012

For evaluation of the rheological and mechanical properties of highly filled wood plastic composites (WPCs), polypropylene/polyethylene (PP/PE) blends were grafted with maleic anhydride (MAH) to enhance the interfacial adhesion between wood fiber and matrix. WPCs were prepared from wood fiber up to 60 wt.% and modified PP/PE was blended by extrusion. The rheological properties were studied by using dynamic measurement. According to the strain sweep test, the linear viscoelastic region of composites in the melt was determined. The result showed that the storage modulus was independent of the strain at low strain region (<0.1%). The frequency sweep results indicated that all composites exhibited shear thinning behavior, and both the storage modulus and complex viscosity of MAH modified composites were decreased comparing to those unmodified. Flexural properties and impact strength of the prepared WPCs were measured according to the relevant standard specifications. The flexural and impact strength of the manufactured composites significantly increased and reached a maximum when MAH dosage was 1.0 wt.%, whereas the flexural modulus after an initial decreased, also increased with MAH dosage. The increase in mechanical properties indicated that the presence of anhydride groups enhanced the interfacial adhesion between wood fiber and PP/PE blends.