demonstrate that the hypophosphite preparations now on the market are woefully below standard and more care must be used in their manufacture than has been done heretofore.
INFLUENCE
muscle. After allowing the heart to return to normal by perfusing with Ringer's solution only, the above effects of the drug could be demonstrated as often as desired. This increase in amplitude was accompanied by either a slight decrease or no change in the rate.When the concentration of the drug was increased to one in 300 there was a marked decrease in the relaxation of the ventricle and in a short time the heart was arrested in systole; there was also a decrease in the number of impulses sent out by the sinus so that the heart was slowed.Pancoast' found the fruit of IEex opaca to contain tannin, pectin, albumin and 2 crystalline principles and organic salts of potassium calcium and magnesium. Venable2 extracted from the leaves of the Yopon (Ilen: cmsene, Linn.) a white crystalline substance which he believed to be caffeine. In some respects the tracings made in this work resemble those obtained by Heathcotes and by Roth4 on perfusion of the frog's heart with the zanthine compounds. However, on close examination there are certain features such as the systolic standstill which suggest a digitalis-like action.An attempt to isolate the principle responsible for the characteristic effects and a more extensive investigation of the pharmacological action of the drug is now being carried out.Recent studies in this laboratory have confirmed the results of Payne, Peenan and Cortland,' Haterius and Pfiffner,' and Macht, Stickels and co-workers3 on the inhibition of normal ovarian activity by preparations of the corpus luteum.
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