SUMMARY One of the causes of anaemia in rheumatoid arthritis is thought to be defective iron absorption. In this study the 59Fe absorption in patients with active rheumatoid arthritis is measured and correlated with the results for bone marrow iron stores (and in some cases with the iron stores in the terminal duodenum), which were assessed simultaneously with semiquantitative methods, and with the serum ferritin concentration. In 11 patients with rheumatoid arthritis and increased bone marrow iron stores, iron absorption was decreased. In five patients it was normal and in three further patients, whose bone marrow iron stores were depleted, iron absorption was maximally increased. According to the results both intestinal malabsorption and defective iron absorption can be excluded as causes.
Bei 2812 Erstblutspendern wurden Eisenstoffwechselparameter im Blut untersucht. Das Serum-Ferritin war im Mittel bei den Frauen signifikant niedriger als bei den Männern (31 vs 86µg/l). 43% der Frauen und 6% der Manner wiesen initial ein erniedrigtes Serum-Ferritin als Zeichen von erschöpften Eisenreserven auf, was die immer noch hohe Prävalenz von Eisenmangel in Deutschland aufzeigt. Bei 60 Erst-spendern mit erhöhtem Serum-Eisen bzw. erhöhtem Serum-Ferritin wurde mit einem biomagnetometrischen Verfahren nichtinvasiv die Leber-Fe-Konzentration gemessen. Eine manifeste Eisenüberladung bei homozygoter hereditärer Hämochromatose wurde bei 7 von 2812 Probanden festgestellt. Dies bestätigt die hohe Prävalenz dieser Erbkrankheit von zirka 1:400 auch für den norddeutschen Raum.
Tumoral calcinosis is a rare benign disease entity that mimics a neoplasm and is manifested by calcium deposition in the soft tissues around the large joints. It can be primary or secondary to renal failure and hyperparathyroidism. This is, to our knowledge, the first reported case of tumoral calcinosis in a Hispanic male with rheumatoid arthritis.
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