Acute Leukemia is a life-threatening disease common both in children and adults that can lead to death if left untreated. Acute Lymphoblastic Leukemia (ALL) spreads out in children's bodies rapidly and takes the life within a few weeks. To diagnose ALL, the hematologists perform blood and bone marrow examination. Manual blood testing techniques that have been used since long time are often slow and come out with the less accurate diagnosis. This work improves the diagnosis of ALL with a computer-aided system, which yields accurate result by using image processing and deep learning techniques. This research proposed a method for the classification of ALL into its subtypes and reactive bone marrow (normal) in stained bone marrow images. A robust segmentation and deep learning techniques with the convolutional neural network are used to train the model on the bone marrow images to achieve accurate classification results.Experimental results thus obtained and compared with the results of other classifiers Naïve Bayesian, KNN, and SVM. Experimental results reveal that the proposed method achieved 97.78% accuracy. The obtained results exhibit that the proposed approach could be used as a tool to diagnose Acute Lymphoblastic Leukemia and its sub-types that will definitely assist pathologists. K E Y W O R D Sacute lymphoblastic leukemia, bone marrow, deep learning, segmentation and classification

Due to a rapidly increasing aging population and its associated challenges in health and social care, Ambient Assistive Living has become the focal point for both researchers and industry alike. The need to manage or even reduce healthcare costs while improving the quality of service is high government agendas. Although, technology has a major role to play in achieving these aspirations, any solution must be designed, implemented and validated using appropriate domain knowledge. In order to overcome these challenges, the remote real-time monitoring of a person's health can be used to identify relapses in conditions, therefore, enabling early intervention. Thus, the development of a smart healthcare monitoring system, which is capable of observing elderly people remotely, is the focus of the research presented in this paper. The technology outlined in this paper focuses on the ability to track a person's physiological data to detect specific disorders which can aid in Early Intervention Practices. This is achieved by accurately processing and analysing the acquired sensory data while transmitting the detection of a disorder to an appropriate career. The finding reveals that the proposed system can improve clinical decision supports while facilitating Early Intervention Practices. Our extensive simulation results indicate a superior performance of the proposed system: low latency (96% of the packets are received with less than 1 millisecond) and low packets-lost (only 2.2% of total packets are dropped). Thus, the system runs efficiently and is cost-effective in terms of data acquisition and manipulation.

The property of nonlinearity has high importance for the design of strong substitution boxes. Therefore, the development of new techniques to produce substitution boxes with high values of nonlinearity is essential. Many research papers have shown that optimization algorithms are an efficient technique to obtain good solutions. However, there is no reference in the public literature showing that a heuristic method obtains optimal nonlinearity unless seeded with optimal initial solutions. Moreover, the majority of papers with the best nonlinearity reported for pseudo-random seeding of the algorithm(s) often achieve their results with the help of some cost function(s) over the Walsh–Hadamard spectrum of the substitution. In the sense, we proposed to present, in this paper, a novel external parameter independent cost function for evolving bijective s-boxes of high nonlinearity, which is highly correlated to this property. Several heuristic approaches including GaT (genetic and tree), LSA (local search algorithm), and the Hill Climbing algorithm have been investigated to assess the performance of evolved s-boxes. A performance comparison has been done to show the advantages of our new cost function, with respect to cost functions for s-boxes like Clark’s and Picek’s cost functions.

Knee bone diseases are rare but might be highly destructive. Magnetic resonance imaging (MRI) is the main approach to identify knee cancer and its treatment. Normally, the knee cancers are pointed out with the help of different MRI analysis techniques and latter image analysis strategies understand these images. Computer-based medical image analysis is getting researcher's interest due to its advantages of speed and accuracy as compared to traditional techniques. The focus of current research is MRI-based medical image analysis for knee bone disease detection. Accordingly, several approaches for features extraction and segmentation for knee bone cancer are analyzed and compared on benchmark database. Finally, the current state of the art is investigated and future directions are proposed.

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This survey provides an overview of popular pathfinding algorithms and techniques based on graph generation problems. We focus on recent developments and improvements in existing techniques and examine their impact on robotics and the video games industry. We have categorized pathfinding algorithms based on a 2D/3D environment search. The aim of this paper is to provide researchers with a thorough background on the progress made in the last 10 years in this field, summarize the principal techniques, and describe their results. We also give our expectations for future trends in this field and discuss the possibility of using pathfinding techniques in more extensive areas.

The recent developments of deep learning support the identification and classification of lung diseases in medical images. Hence, numerous work on the detection of lung disease using deep learning can be found in the literature. This paper presents a survey of deep learning for lung disease detection in medical images. There has only been one survey paper published in the last five years regarding deep learning directed at lung diseases detection. However, their survey is lacking in the presentation of taxonomy and analysis of the trend of recent work. The objectives of this paper are to present a taxonomy of the state-of-the-art deep learning based lung disease detection systems, visualise the trends of recent work on the domain and identify the remaining issues and potential future directions in this domain. Ninety-eight articles published from 2016 to 2020 were considered in this survey. The taxonomy consists of seven attributes that are common in the surveyed articles: image types, features, data augmentation, types of deep learning algorithms, transfer learning, the ensemble of classifiers and types of lung diseases. The presented taxonomy could be used by other researchers to plan their research contributions and activities. The potential future direction suggested could further improve the efficiency and increase the number of deep learning aided lung disease detection applications.

Visual inspection for the quantification of malaria parasitaemiain (MP) and classification of life cycle stage are hard and time taking. Even though, automated techniques for the quantification of MP and their classification are reported in the literature. However, either reported techniques are imperfect or cannot deal with special issues such as anemia and hemoglobinopathies due to clumps of red blood cells (RBCs). The focus of the current work is to examine the thin blood smear microscopic images stained with Giemsa by digital image processing techniques, grading MP on independent factors (RBCs morphology) and classification of its life cycle stage. For the classification of the life cycle of malaria parasite the k‐nearest neighbor, Naïve Bayes and multi‐class support vector machine are employed for classification based on histograms of oriented gradients and local binary pattern features. The proposed methodology is based on inductive technique, segment malaria parasites through the adaptive machine learning techniques. The quantification accuracy of RBCs is enhanced; RBCs clumps are split by analysis of concavity regions for focal points. Further, classification of infected and non‐infected RBCs has been made to grade MP precisely. The training and testing of the proposed approach on benchmark dataset with respect to ground truth data, yield 96.75% MP sensitivity and 94.59% specificity. Additionally, the proposed approach addresses the process with independent factors (RBCs morphology). Finally, it is an economical solution for MP grading in immense testing.