CCAL1, a member of the tumor necrosis factor receptor superfamily 11B, encodes osteoprotegerin. We report that CCAL1 is highly expressed in osteoarthritis (OA) tissues and Human Chondrocyte‐Osteoarthritis (HC‐OA) cells and its expression level is positively correlated with the severity of OA. CCAL1 could activate NF‐κB and inhibit AMPK pathways to promote HC‐OA cell fibrosis, viability and proliferation.
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