Electrochemically
driven, Cp*Ir(III)-catalyzed regioselective annulative
couplings of benzoic acids with alkynes have been established herein.
The combination of iridium catalyst and electricity not only circumvents
the need for stoichiometric amount of chemical oxidant, but also ensures
broad reaction compatibility with a wide array of sterically and electronically
diverse substrates. This electrochemical approach represents a sustainable
strategy as an ideal alternative and supplement to the oxidative annulations
methodology to be engaged in the synthesis of isocoumarin derivatives.
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