Although immunotherapy has achieved recent clinical success in antitumor therapy, it is less effective for solid tumors with large burdens. To overcome this challenge, herein, we report a new strategy based on platelet membrane-camouflaged aggregation-induced emission (AIE) luminogen (Plt-M@P) combined with the antiprogrammed death ligand 1 (anti-PD-L1) for tumoral photodynamic-immunotherapy.Plt-M@P is prepared by using poly lactic-co-glycolic acid (PLGA)/PF3-PPh 3 complex as a nanocore, and then by co-extrusion with platelet membranes. PF3-PPh 3 is an AIE-active conjugated polyelectrolyte with photosensitizing capability for photodynamic therapy (PDT). Plt-M@P exhibits superior tumor targeting capacity in vivo.
A series of new conjugated polyelectrolytes (CPEs) with emissive tetraphenylethene-containing backbones and specific targeting pendants are synthesized and characterized.
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