Red AIE conjugated polyelectrolytes for long-term tracing and image-guided photodynamic therapy of tumors

Yao, Hongming; Dai, Jun; Zhuang, Zeyan; Yao, Jinya; Wu, Zhenqiang; Wang, Shixuan; Xia, Fan; Zhou, Jian; Lou, Xiaoding; Zhao, Zujin

doi:10.1007/s11426-020-9824-2

Cited by 35 publications

(29 citation statements)

References 67 publications

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“…P2-PPh3 (structure shown in Fig. S1a) was synthesized according to our previous report [ 35 ]. P2-PPh3 is a conjugated polyelectrolyte (CPE) showing AIE properties with enhanced emission in co-solvent systems that have high fractions of tetrahydrofuran (THF), a poor solvent for P2-PPh3 (Fig.…”

Section: Resultsmentioning

confidence: 99%

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

Dai

Wang

et al. 2021

National Science Review

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Red blood cell (RBC)-mimicking nanoparticles (NPs) are a promising platform for drug delivery owing to their prolonged circulation time, reduced immunogenicity, and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs (M@AP), for tumoral photodynamic-immunotherapy. M@AP is formed by the self-assembly of the positively charged aggregation-induced emission luminogen (AIEgen) (named P2-PPh3) and the negatively charged polyinosinic: polycytidylic acid (Poly(I: C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with the additional photosensitizing ability for photodynamic therapy (PDT), while Poly(I: C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region owing to the enhanced permeability and retention (EPR) effect and the spleen due to the homing effect of the RBC mimicking shell. Upon light-irradiation, P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens (TA). The anti-tumor immunity is further enhanced by the presence of Poly(I: C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I: C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment.

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Section: Resultsmentioning

confidence: 99%

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

Dai

Wang

et al. 2021

National Science Review

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“…To observe the detailed intracellular damaging process, we further studied the phototoxicity and selectivity of 7D12‐NBS by fluorescence imaging. The Calcein AM‐PI kit was used for live/death cells imaging, [ 26 ] in which Calcein AM can label live cells with green fluorescence and PI can label death cells with red fluorescence. As shown in Figure 5f, all the groups in dark showed only green fluorescence, indicating the excellent biosafety of 7D12‐NBS .…”

Section: Resultsmentioning

confidence: 99%

A Novel Nanobody–Photosensitizer Conjugate for Hypoxia Resistant Photoimmunotherapy

Xiong

Peng

Chen

et al. 2021

Adv Funct Materials

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As a non‐invasive treatment modality, photodynamic therapy has been a potential therapeutic method for metastatic and non‐metastatic tumors. In order to further improve the tumor selectivity, phtotoimmunotherapy (PIT) has been developed recently, which includes antibodies as the active targeting ligands. However, traditional monoclonal antibody‐based PIT suffers from long half‐lives and extended phototoxic side‐effects in vivo. Herein, a type I mechanism‐based photoimmunoconjugate (PIC) is developed by incorporating anti‐EGFR nanobody as the targeting ligand, and benzophenothiazine as the photosensitizer (PS). The small size and robust structure of the nanobody ensures excellent targeting accuracy and efficient renal excretion. Meanwhile, the type I PS is able to circularly transfer oxygen to superoxide radical upon irradiation to overcome hypoxia microenvironment. The PIC showed satisfying phototherapeutic ability both in normoxia and hypoxia, and displayed high selectivity towards tumor in vivo. By combining nanobody and Type I PS, the work presents a novel type of PIC for the precise treatment of tumors with high specificity and potency.

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“…The polymer with 1.94 eV bandgap can be used for PDT, but the PDT efficiency needs to be further studied. Zhou et al 72 reported polymer P41 with aggregation-induced emission (AIE) characteristics, red emission peak at 638–649 nm, and 25.0–30.6% fluorescence quantum yield in the aggregated state. It is suitable for PDT as a PS.…”

Section: Linear Scpsmentioning

confidence: 99%

“…Second, SCPs can induce subcellular organelle-mediated cell death under light, such as lysosome and mitochondria. Triphenylphosphine bromide (TPP), 72 TAPP 181 and Met 153 have been used as mitochondrial targeting agents for SCPs. In addition to the two abovementioned types of organelles, there are the cell membrane and nucleus, and the detailed content can be referred to other reviews.…”

Section: Issues and Strategies For Enhanced Pdtmentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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Photodynamic therapy (PDT) is a noninvasive therapy for cancer and bacterial infection. Metal-free semiconducting conjugated polymers (SCP S ) with good stability and optical and electrical properties are promising photosensitizers (PSs) for PDT compared with traditional small-molecule PSs. This review analyzes the latest progress of strategies to improve PDT effect of linear, planar, and three-dimensional SCP S , including improving solubility, adjusting conjugated structure, enhancing PS-doped SCPs, and combining therapies. Moreover, the current issues, such as hypoxia, low penetration, targeting and biosafety of SCP S, and corresponding strategies, are discussed. Furthermore, the challenges and potential opportunities on further improvement of PDT for SCPs are presented.

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Red AIE conjugated polyelectrolytes for long-term tracing and image-guided photodynamic therapy of tumors

Cited by 35 publications

References 67 publications

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy

A Novel Nanobody–Photosensitizer Conjugate for Hypoxia Resistant Photoimmunotherapy

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

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