Different culture conditions directed by the OSMAC (one strain-many compounds) approach drastically modified the metabolites of the fungus Spicaria elegans, which yielded the novel spicochalasin A (1), five new aspochalasins M-Q (2-6), and two known aspochalasins (7 and 8). The gross structures of 1-6 were elucidated by 1D and 2D NMR and MS methods, and their absolute configurations were determined by X-ray

Graphical abstract

No abstract

Three new cytochalasins Z(21) -Z(23) (1-3, resp.), together with five analogs, 4-8, were isolated from Spicaria elegans KLA03 by the OSMAC (one strain-many compounds) approach with adding L- and D-tryptophan during its cultivation. The structures of new cytochalasins were elucidated on the basis of comprehensive 1D- and 2D-NMR and HR-ESI-MS analyses. Cytochalasins Z(21) and Z(22) (1 and 2, resp.), and compound 5 showed cytotoxic activities against A-549 cell lines with IC(50) values of 8.2, 20.0, and 3.1 μM, respectively.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.