Bacterial infections are a serious ongoing threat to human health. As such, within the context of modern technology, there is an urgent need to develop fluorescent probes suitable for diagnosing bacterial infections in vivo. Herein, we synthesize NaGdF 4 :Nd@NaGdF 4 core-shell down-conversion nanoparticles (DCNPs) demonstrating excellent emission intensity in the second nearinfrared (NIR-II) window for use as fluorescent probes to enable high-quality imaging of pathogenic infections. The fluorescent probe is covalently linked with vancomycin (Van), which specifically binds to Gram-positive bacteria such as S. aureus. Both in vitro detection and in vivo imaging results show that the Vanmodified NIR-II fluorescent probe can distinguish Gram-positive from Gram-negative bacteria with a high degree of selectivity. Biocompatibility is verified by MTT assay and histological analyses.
Bacterial diseases pose a serious threat to human health. Continued development of precise diagnostic methods and synergistic therapy techniques for combating bacteria are needed. Herein a hybrid nanosystem (Ag2S@ZIF-Van NS)...
The ability to accurately characterize microorganism distribution in the intestinal tract is helpful for understanding intrinsic mechanisms. Within the intestine, traditional optical probes used for microorganism labeling commonly suffer from a low imaging penetration depth and poor resolution. We report a novel observation tool useful for microbial research by labeling near-infrared-IIb (NIR-IIb, 1500−1700 nm) lanthanide nanomaterials NaGdF 4 :Yb 3+ ,Er 3+ @NaGdF 4 ,Nd 3+ (Er@Nd NPs) onto the surface of Lactobacillus bulgaricus (L. bulgaricus) via EDC-NHS chemistry. We monitor microorganisms in tissue by two-photon excitation (TPE) microscopy and in vivo with NIR-IIb imaging. This dual-technique approach offers great potential for determining the distribution of transplanted bacteria in the intestinal tract with a higher spatiotemporal resolution.
A visible-light-active CuInSe2:Zn/g-C3N4/TiO2 nanowire (NW) photoelectrode was prepared by in situ growth of g-C3N4 on the surface of TiO2 NWs, followed by drop deposition of Zn-doped CuInSe2 quantum dots (CuInSe2:Zn QDs).
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