Oncology inpatients are at high risk of malnutrition. Identification of at risk patients by nutrition screening requires a practical and easy to use tool. The aim of this study was to determine the validity of the Bach Mai Boston Tool (BBT) compared to a ‘gold standard’ full nutrition assessment using the Patient-Generated Subjective Global Assessment (PG-SGA). A cross-sectional study was conducted on 270 oncology inpatients from January to December 2016. Cohen’s Kappa, sensitivity, specificity and ROC analyses were performed. 270 inpatients were included in this study with a mean age of 56.3 ± 12.1 years old. Of these patients, 51.8% were male, and 74.1% had gastrointestinal cancer. The mean body mass index of patients was 20.6 ± 3.0 kg/m2. The PG-SGA tool identified 146 (54.1%) malnourished patients, while the BBT identified 105 (39.9%) malnourished patients. The BBT had a medium consistency, with a Kappa value of 0.6. Using a cut-off point of ≥ 4, the BBT had a sensitivity of 87.7% and a specificity of 72.6%. On the other hand, a BBT with a cut-off point ≥ 5 resulted in a sensitivity of 67.1%, a specificity of 94.4%, and an AUC of 0.81. The BBT is a practical, informative and valid tool for detecting malnutrition in hospitalized oncology patients. We recommend using a cut-off point of 4 for screening the risk of malnutrition for oncology inpatients.
Background: Esophagus cancer patients are at high risk of malnutrition. This study was performed to assess the nutritional status and dietary intake of newly diagnosed esophageal cancer patients in Vietnam National Cancer Hospital (NCH). Methods: A cross-sectional study was conducted on 206 early esophageal cancer inpatients after gastrostomy from September 2017 to June 2018. The chi-squared test, Fisher exact test, and Mann–Whitney test were performed. The software of the Vietnam National Institute of Nutrition was used to evaluate the dietary intake of patients. Results: All the participants were male with a mean age of 57.1 ± 8.5 years. Overall, 87.4% of patients had dysphagia. Furthermore, 82.5% and 90.8% of patients reported weight loss one and six months pre-diagnosis, respectively. Moreover, 52.9% of patients suffered from mild/moderate malnutrition and 29.6% of patients had severe malnutrition according to the Patient-Generated Subjective Global Assessment (PG-SGA). The body mass index (BMI) and mid upper arm circumference (MUAC) measurement revealed 47.6% and 50% of undernourished patients, respectively. The proportions of patients having malnutrition were 10.7%, 55.8%, and 27.2% according to albumin, prealbumin, and total lymphocyte counts, respectively. The means of energy, protein, lipid, and carbohydrate in the patients’ 24 h preoperative diets were 973.6 ± 443.0 kcal/day, 42.4 ± 21.6 g/day, 31.0 ± 15.5 g/day, and 130.0 ± 64.5 g/day. The total energy, total protein, animal protein, total lipid, and plant lipid in the dietary intake of patients were strongly correlated with age, economic classification, and PG-SGA (each p < 0.05). The total energy intake increased day by day, with the average energy intake of 1343.9 ± 521.3 kcal on the seventh day. Energy and protein response rates increased day by day and were highest at 7 days post-operation at 18.0% and 19.4%. Conclusion: Malnutrition and insufficient intake are noteworthy in esophageal cancer patients. The PG-SGA is strongly correlated with the dietary intake of patients. The results from this study will help medical staff to prevent malnutrition and improve the nutritional status of esophageal cancer inpatients. Furthermore, public awareness should be raised on recognizing weight loss as an early symptom of esophageal cancer and the utilization of preoperative assessment tools for nutritional assessment and malnutrition management.
Background: In Pharmacovigilance, spontaneous reporting of adverse drug reactions is the most common method used in many countries around the world to detect and monitor adverse drug reactions. Among sources of ADR reports, reports performed at health facilities play an important role in detecting adverse drug reactions of newly introduced drugs, serious adverse reactions, and adverse drug reactions which can be detected early. Objectives: (1) To investigate the implementation of adverse drug reaction reporting activities at Hue University of Medicine and Pharmacy Hospital for the period 2017-2019, (2) To analyze activities of reporting adverse reactions of drugs at Hue University of Medicine and Pharmacy Hospital for the period of 2017-2019. Materials and methods: We performed a descriptive cross-sectional study on pharmacists who reported ADR and a total of 138 ADR reports archived at pharmacy department of the hospital. Results and Conclusions: The groups of evaluation criteria for the management organization, resources and communication activities related to the adverse drug reaction reporting were scored over 75% of the maximum. In 2017, the reporting rate compared to the whole country reached 0.62% and decreased to 0.37% in 2019. The proportion of good quality reports increased from 34.62% in 2017 to 91.49% in 2019. Almost ADR reports came from nurses (85.51%). The other beta - lactam antibacterial group was the most reported group of suspect drugs (52.17%). The most reported pairs of drugs - adverse reactions were Ceftriaxon - rash (13.04%), Ceftriaxon - pruritus (7.97%) and Ceftriaxon - vomiting (7.97%). Key words: Pharmacovigilance, adverse drug reactions, medical facility
Patient: Male, 52-year-old Final Diagnosis: Hypopharyngeal cancer Symptoms: Dysphagia Medication:— Clinical Procedure: Surgery and radiotherapy Specialty: Oncology • Surgery Objective: Rare disease Background: Esophageal invasion in hypopharyngeal cancer is an uncommon lesion and has a poor prognosis. Total pharyngo-laryngo-esophagectomy is the most effective treatment option. Reconstruction of the gastrointestinal tract in the same period of surgery is required. There are many different options, such as pedicle flap, gastric pull-up, pedicled transverse colon flaps, and free flap. In cases where only cervical esophagectomy is required, with benefits for patients, jejunal free flap is the first choice to reconstruct the esophagus. However, the extensive surgical resection requires interdisciplinary collaboration among surgical specialities, which is not always available. Case Report: A 52-year-old male patient came to us with a chief concern of dysphagia, which first appeared 3 months ago. Rigid fiberoptic and direct laryngoscopes indirectly observed the tumor at the posterior wall; it had passed the esophagus opening and infiltrated to the cervical esophagus, with the rightmost part spread into the right pyriform sinus. Histopathology studies of the tumor showed a squamous cell carcinoma. The patient underwent total pharyngo-laryngo-cervico-esophagectomy, reconstructed with a jejunal free flap, and adjuvant radiation therapy after surgery. At follow-up 1 year after surgery, the patient was significantly recovery with no signs of tumor recurrence, no difficulties of oral intake, and his speech was restored by electrolarynx. Conclusions: We reported the case of a patient with hypopharyngeal cancer who underwent total pharyngo-laryngo-cervicoesophagectomy and esophagus reconstruction using a jejunal free flap, performed for the first time in Vietnam. As expected, with good oncological and functional results, the degree of invasiveness and sequelae of the surgery can be well tolerated.
Background: Duchene muscular dystrophy (DMD) is an X-linked inherited neuromuscular disorder due to mutations in the dystrophin gene. It is characterized by progressive muscle weakness and wasting due to the absence of dystrophin protein that causes degeneration of skeletal and cardiac muscle. Aims of this study were to evaluate functional independence of DMD patients. Methods: The study included 30 patients with DMD diagnosed and managed at Department of Endocrinology, Metabolism and Genetics, National Children's Hospital in 2016. This is a cross-sectional study using WeeFIM questionnaire (self-care, mobility and cognition) for the parents or caregivers.
Background: Hunter syndrome or mucopolysaccharidosis type II (MPS II) is caused by deficiency of lysosomal enzyme iduronate-2-sulfatase and characterized by neurologic and movement functions. Aims: To evaluate functional independence for patients with Hunter syndrome. Methods: Study included 17 patients with Hunter syndrome diagnosed and managed at Department of Endocrinology, Metabolism and Genetics, National Children's Hospital in 2016. This is a cross-sectional study using WeeFIM questionnaire (self-care, mobility and cognition) for the parents or caregivers. Results: The percentage of patients needed total assistance of self-care was 35.9%, and only 4.69% of patients were complete independence of self-care. Mobility ability with supervision was 41.25% of patients, and patients with complete independence on mobility account for 11.25%. Only 12.5% patients had complete independence on communication. Conclusions: All self-care, mobility and communication of patients with Hunter syndrome were affected, and patients need assistance from their parents or caregivers.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.