Cellulaseassisted microwave extraction of polysaccharides from Elaeagnus angustifolia L. was researched. The four influential parameters, extraction temperature, pH value, microwave extraction power and microwave time, were optimized using the Box-Behnken design (BBD) with a quadratic regression model built by using response surface methodology (RSM). As results, the extraction conditions have significant effects on extraction yield of polysaccharide, a quadratic model was found to fit for EAP yield, and the optimal conditions was determined as following: extraction temperature of 38°C,pH value of 5.0,microwave power of 509W and irradiation time of 60 s. A maximum yield of 19.57± 0.02% for EAP was achieved in verification experiment.
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