To determine the involvement of human cytomegalovirus (CMV)

Pathological examination was carried out on 16 male Sprague-Dawley rats received single i. v. injection of 60 mg/kg of streptozotocin (SZ) at 5 weeks of age and maintained for 22 months. Insulinoma (63 %), renal adenoma (50 %), hepatocellular tumor (69 %), cholangioma (31 %) and Leydig cell tumor (56 %) were found in a high incidence, and therefore occurrence of these tumors was considered to be attributable to the treatment with SZ. In addition to these tumors, though in a low incidence, various such tumors as leukemia, reticulum cell sarcoma, mammary tumor and glioma were also found.

We report a case of severe hypoglycemia and hepatic masses suspected to be an insulin‐like growth factor‐II (IGF‐II)‐producing hepatocellular carcinoma. A 62‐year‐old man presented with mental disorder in the night and early morning associated with extremely low blood sugar levels (> 21 mg/dl). Computerized axial tomography and ultrasonography revealed a massive tumor in the right lobe of the liver with multiple secondary nodules, and a tumor thrombus in the portal vein. At autopsy 107 days after admission, the liver weighed 3070 g, histologically showing an Edmondson type II tumor with liver cirrhosis. IGF‐II in plasma (899 ng/ml) and tumor tissue (2.4 μg/g) was higher than that in normal plasma (374–804 ng/ml) and non‐tumor liver tissue (0.2 μg/ml), while IGF‐I (14 ng/ml) was significantly reduced. IGF‐II, probably produced by the liver tumor, appeared to be involved in the mechanism of hypoglycemia.

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