and SUZUKI, M. Concurrent Endometrial Hyperplasia with Carcinoma of the Corpus Uteri. Tohoku J. exp. Med., 1985, 145 (1), [15][16][17][18][19][20][21][22] Using 117 uteri which were extirpated in cases of carcinoma of the corpus uteri, a study was made to investigate the relationship between the site of the cancer and the site of associated endometrial hyperplasia. It was found that 75% of the cases had carcinomas of the upper portion of the uterus primarily of the uterine fundus. About 50% of the cancers were associated with adenomatous or atypical hyperplasia, and these two types of hyperplasia were frequently found in the fundus or upper portion of the uterus. In contrast, there was no site of particular prevalence in cases with concurrent cystic hyperplasia. About 70% of the cases had adenomatous or atypical hyperplasia on one or both of the histological blocks adjacent to the cancer. endometrial hyperplasia ; cystic hyperplasia ; adenomatous hyperplasia ; atypical hyperplasia ; endometrial carcinoma.The incidence rate of carcinoma of the corpus uteri in Japan is approximately 1/10 that of carcinoma of the uterine cervix. In recent years, however, there has been an increase in the incidence of cancers of the corpus (Silverberg et al. 1982).Research on the clinical pathology of carcinoma of the corpus uteri, particularly on the precursors of such lesions, is far behind that on cancers of the cervical region. The reasons for this imbalance may be due to the fact that follow-up of endometrial hyperplasia, which is thought to be a precursor of carcinoma of the corpus uteri, could not be done in a safe and unambiguous manner. Moreover, as mentioned above, it is also true that the incidence of cancers of the corpus is much lower than that of cervical cancers, at least in Japan.In the present study, we have retrospectively investigated the significance of concurrent endometrial hyperplasia as a possible precursor to carcinoma in uteri excised because of the presence of carcinoma of the corpus uteri.Received for publication, March 30, 1984. 15 16 A. Yaj ima et al.
MATERIALS AND METHODS
investigation was made of the effects on cure rate of postoperative radiotherapy following radical hysterectomy with lymphadenectomy for cases of invasive carcinoma of the uterine cervix performed over 7 years between 1969 and 1975 at the Department of Obstetrics and Gynecology, Tohoku University Hospital. For cases in which resection was complete but the cancer extended to the pelvic wall, the 5 year survival rate was similar to that in comparable cases of the same clinical stage regardless of whether or not postoperative radiotherapy was employed. The 5 year survival rate in cases undergoing postoperative radiotherapy because of lymph node metastasis was lower than that of cases where the lesion approached the pelvic wall and for which postoperative radiotherapy was employed. An investigation of the 5 year survival rate among those cases with lymph node metastasis and receiving postoperative radiotherapy indicated that survival in cases with metastasis to only one lymph node was similar to that of cases of the same clinical stage which received the operation only, whereas the survival rate of cases with multiple lymph node involvement was markedly lower. ----cervical cancer; postoperative radiotherapy; treatment of cervical cancer; external irradiation
We observed an unusual case of a woman who had received a gonadotropinreleasing hormone (GnRH) agonist (GnRH‐a), leuprolide acetate, during the first trimester and early in the second trimester of pregnancy. Nevertheless, the pregnancy was uncomplicated and a healthy male infant (2,670 g) was born after spontaneous labor at the 38th week of gestation. The infant suffered no malformations or respiratory complication and he achieved normal growth. Although GnRH‐a is known to induce pregnancy loss, the drug does not appear to be teratogenic. Accordingly, a pregnancy that occurs during GnRH‐a therapy and progresses normally should not be terminated for fear of its teratogenic effects.
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