Concurrent endometrial hyperplasia with carcinoma of the corpus uteri.

Abstract

and SUZUKI, M. Concurrent Endometrial Hyperplasia with Carcinoma of the Corpus Uteri. Tohoku J. exp. Med., 1985, 145 (1), [15][16][17][18][19][20][21][22] Using 117 uteri which were extirpated in cases of carcinoma of the corpus uteri, a study was made to investigate the relationship between the site of the cancer and the site of associated endometrial hyperplasia. It was found that 75% of the cases had carcinomas of the upper portion of the uterus primarily of the uterine fundus. About 50% of the cancers were associated with adenomatous or atypical hyperplasia, and these two types of hyperplasia were frequently found in the fundus or upper portion of the uterus. In contrast, there was no site of particular prevalence in cases with concurrent cystic hyperplasia. About 70% of the cases had adenomatous or atypical hyperplasia on one or both of the histological blocks adjacent to the cancer. endometrial hyperplasia ; cystic hyperplasia ; adenomatous hyperplasia ; atypical hyperplasia ; endometrial carcinoma.The incidence rate of carcinoma of the corpus uteri in Japan is approximately 1/10 that of carcinoma of the uterine cervix. In recent years, however, there has been an increase in the incidence of cancers of the corpus (Silverberg et al. 1982).Research on the clinical pathology of carcinoma of the corpus uteri, particularly on the precursors of such lesions, is far behind that on cancers of the cervical region. The reasons for this imbalance may be due to the fact that follow-up of endometrial hyperplasia, which is thought to be a precursor of carcinoma of the corpus uteri, could not be done in a safe and unambiguous manner. Moreover, as mentioned above, it is also true that the incidence of cancers of the corpus is much lower than that of cervical cancers, at least in Japan.In the present study, we have retrospectively investigated the significance of concurrent endometrial hyperplasia as a possible precursor to carcinoma in uteri excised because of the presence of carcinoma of the corpus uteri.Received for publication, March 30, 1984. 15 16 A. Yaj ima et al. MATERIALS AND METHODS

Pollakisuria in a dwarf goat due to pathologic enlargement of the uterus

“…It is assumed to originate from deep uterine glands (6). Stimulation of these glands by chronic hyperoestrogenism is considered a risk factor for malignancy (26). For this reason, adenocarcinomas of the uterus are often oestrogensensitive (12).…”