Twenty five children with chronic otitis media with effusion received low-dose and long-term erythromycin treatment (EM treatment), and the clinical and bacteriological effects were studied. After the EM treatment, resolution of middle ear effusion (MEE) was observed in 18 of the 25 patients. Within the 3-month follow-up period after EM treatment, 13 of the 18 patients were completely effusion-free, while recurrence of MEE was observed in 5 cases. The final rate of resolution, therefore, was 52%. EM treatment was not effective for younger children, especially for those under 2 years of age.Patients with accompanying chronic sinusitis tended to become effusion-free after EM treatment along with reduction of their nasal symptoms. Persistence of nasopharyngeal pathogens during the EM treatment was demonstrated, indicating that the resolution of MEE by the treatment did not depend on antimicrobial effects but on some antiinflammatory effects. The present results show that EM treatment can increase the resolution of MEE in children with OME.
It is not uncommon for otolaryngologists to encounter laryngeal edema due to infection in routine practice. However, we rarely encounter laryngeal edema caused by allergic reactions to orally ingested food. We herein report two cases of oral allergy syndrome after consumption of manuka honey candy. Both cases developed laryngeal edema and subsequent steroid administration led to the prompt improvement of symptoms. A basophil activation test for manuka honey candy was negative in both cases.
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