A 26 year old pregnant woman with antithrombin III deficiency developed recurrent septicaemia with Serratia marcescens. In spite of the administration of antibiotics, high grade fever persisted. She subsequently manifested lower abdominal pain, and spontaneous abortion occurred. After the abortion, she became completely afebrile. The amnion was turbid, and microscopic examination of the placenta showed haemorrhage and massive infiltration of neutrophils, suggestive of infectious chorioamnionitis. Pulsed field gel electrophoresis showed that isolates from the blood, urine, and vaginal discharge were genetically identical. Intravenous pyelography revealed that she had a bilateral completed double ureter. It was thought that a urinary tract anomaly caused infection with S marcescens, and the pathogen spread to the chorioamnion via the bloodstream. This is the first report of chorioamnionitis caused by S marcescens in a non-immunocompromised host. In addition, these findings indicate that the chorioamnion can serve as a site for persistent infection in normal pregnancies.
An underweight 10-month-old Holstein heifer presented with anorexia and ananastasia and was euthanized. Postmortem examination revealed extensive ulceration in the esophagus, tongue, and
omasum. Histopathological examination revealed severe necrotic esophagitis, glossitis, and omasitis. Many Gram-negative bacilli were detected throughout the necrotic area in the digestive
tract; these were identified as Pseudomonas aeruginosa on the basis of isolation tests, molecular examinations, and immunohistochemistry. Gram-negative long filamentous
organisms in the superficial layers of the necrotic lesions reacted positively with antibodies against Fusobacterium necrophorum subsp. necrophorum. Thus,
the necrotic lesions were confirmed to be associated with P. aeruginosa and Fusobacterium spp. This is the first detection of P. aeruginosa
in bovine esophageal and glossal ulcers associated with Fusobacterium spp.
A Japanese black feedlot steer suddenly died after exhibiting astasia and cramping of the
extremities. Necropsy of the animal revealed that the right kidney was enlarged and pale
with severe nephrolithiasis. The urinary bladder displayed mucosal hemorrhage. Upon
bacteriological investigation, Proteus mirabilis was isolated from the
liver, spleen, right kidney, lungs and urine. Histopathological examination revealed
necrotizing suppurative nephritis with the presence of numerous gram-negative bacilli and
fibrinous suppurative cystitis with no bacilli. Immunohistochemical analysis revealed that
the bacteria and cytoplasm of the macrophages stained positively with P.
mirabilis antiserum. Electron microscopy revealed the presence of numerous
bacteria in the renal tubules. To our knowledge, this is the first report describing the
histopathological aspects of nephritis caused by P. mirabilis in
cattle.
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