We report on a man with bilateral multiple renal oncocytomas who had enlarged kidneys, and presented with loin pain and gross hematuria. A provisional diagnosis of multiple renal oncocytomas was made after renal angiography demonstrated the characteristic appearance of this tumor. The diagnosis was confirmed with histology of an open renal biopsy specimen. This case is unique in that the lesions were multiple and bilateral. The patient had impaired renal function and, hence, the necessity for conservative management once the histological diagnosis had been established. Since in previously reported cases oncocytomas have been removed completely our case provides an opportunity to observe the natural history of the disease.
1. An in vivo stathmokinetic technique was used to determine the immediate effect of various adrenoceptor agonists and antagonists on the mitotic rate in the stratified squamous epithelium of the rat buccal mucosa. 2. The mitotic rate increased significantly in rats treated with propranolol and with practolol, whereas the mitotic rate decreased significantly in rats treated with metaraminol. In animals treated with isoprenaline and phentolamine the mitotic rate did not differ significantly from the control value. 3. The nature of the involvement of adrenergic mechanisms with cell proliferation is still uncertain but both alpha- and beta-adrenergic mechanisms appear to be associated with the control of cell proliferation.
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