Adrenergic factors influencing the mitotic rate in stratified squamous epithelium of the buccal mucosa of the rat

Hunt, Hilary A.; Tutton, P. J. M.

doi:10.1111/j.1440-1681.1976.tb02666.x

Cited by 11 publications

(2 citation statements)

References 8 publications

(3 reference statements)

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“…This is a substantial number, as it translates to 28,595 new HBV infections each year. A publication by the US Center for Disease Control[30] and a study in Nigeria [31] implicated injection from untrained community medical providers, body scarification, sharing of sharp body-piercing instruments, sharing of toothbrushes, and uvulectomy as reasons for the spread of HBV [16]. A relatively high prevalence was demonstrated in a group of Nigerian female civil servants, a finding thought to be related to female circumcision.…”

Section: Introduction and Epidemiologymentioning

confidence: 99%

Chronic Hepatitis B: Management Challenges in Resource-Poor Countries

Nwokediuko

2011

Hpat Mon

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Sylvester Chuks Nwokediuko, Department of Medicine, University of Nigeria Teaching Hospital, Ituku OzallaChronic infection with hepatitis B virus (HBV) is a global public health problem because of its worldwide distribution and its potential to cause sequelae. HBV is most prevalent in China, South East Asia, sub-Saharan Africa, and the Amazon basin of South America where health care resources are most limited. Numerous challenges exist for effective management of chronic HBV infection, particularly in resource-limited regions. These challenges include lack of accurate prevalence data, absence of a surveillance program, and poor political will of governments in resource-poor countries to enforce effective measures to control the disease. There is a lack of understanding regarding HBV infec-tion by both the general public and health care providers. A better understanding of the pathogenesis and treatment of this condition is necessary. The acute shortage of trained medical manpower necessary for accurate diagnosis and treatment of chronic hepati-tis B (CHB) in resource-poor countries is a formidable challenge. The condition is com-plicated by the continuing efflux of medical graduates from low-income economies to richer countries. The most critical problem in the management of CHB is the high cost of laboratory tests and drugs. Drugs are also not readily available. Other challenges in the manage-ment of CHB include stigmatization of patients, co-infection with other viruses, lack of management guidelines, and absence of an effective patient referral system. To address these challenges, governments of resource-poor nations must be committed to budg-etary allocation for the implementation of health programs. It is necessary to provide awareness campaigns, health education, proper screening of blood and blood products for transfusion, active screening, intensification of existing childhood immunization, technical and financial assistance from wealthier nations, and implementation of the recommendations outlined in the Global Hepatitis Policy (2010).

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Section: Introduction and Epidemiologymentioning

confidence: 99%

Chronic Hepatitis B: Management Challenges in Resource-Poor Countries

Nwokediuko

2011

Hpat Mon

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“…Values are available for labelling and mitotic indices of mucosal epithelia of a range of species and anatomical sites. A marked diurnal variation in mitotic activity exists in oral mucosae (Izquierdo & Gibbs 1972;Mackenzie & Hill 1981), and normal activity is altered by a range of factors including stress, a factor of importance when human tissues are collected (BuUough 1967, Skougaard 1970), aand P-adrenergic compounds (Hunt & Tutton 1976), possibly age , and inflammation and trauma (Mackenzie & Miles 1973, Hopps & Johnson 1974.…”

Section: Factors Controlling Rates and Patterns Of Cell Renewal In Ormentioning

confidence: 99%

Recent advances in oral mucosal research

Mackenzie

Binnie

1983

J Oral Pathology Medicine

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Neural control of colonic cell proliferation

Tutton¹,

Barkla²

1980

Cancer

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The mitotic rate in rat colonic crypts and in dimethylhydrazine-induced colonic carcinomas was measured using a stathmokinetic technique. In sympathectomized animals cell proliferation was retarded in the crypts but not in the tumors, whereas in animals treated with Metaraminol, a drug which releases norepinephrine from nerve terminals, crypt cell but not tumor cell proliferation was accelerated. Blockade of alpha-adrenoceptors also inhibited crypt cell proliferation. However, stimulation of beta-adrenoceptors inhibited and blockade of beta-adrenoceptors accelerated tumor cell proliferation without influencing crypt cell proliferation. Injection of either serotonin or histamine stimulated tumor but not crypt cell proliferation and blockade or serotonin receptors or histamine H2-receptors inhibited tumor cell proliferation. It is postulated that cell proliferation in the colonic crypts, like that in the jejunal crypts, is under both endocrine and autonomic neural control whereas colonic tumor cell division is subject to endocrine regulation alone.

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Adrenergic factors influencing the mitotic rate in stratified squamous epithelium of the buccal mucosa of the rat

Cited by 11 publications

References 8 publications

Chronic Hepatitis B: Management Challenges in Resource-Poor Countries

Chronic Hepatitis B: Management Challenges in Resource-Poor Countries

Recent advances in oral mucosal research

Neural control of colonic cell proliferation

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