From first principles calculations, a novel pentagonal Si/C complexity is predicted to have potential applications as a promising anode material for Li-ion batteries. It is found that the structural and thermal stability of the penta-siligraphene (P-Si
2
C
4
) is better than penta-graphene that is composed of C atoms only. Electronic band structure analysis shows that the empty C-2
p
z
state in the P-Si
2
C
4
provides space to accommodate and stabilize electrons from Li, which makes Li storage energetically favorable. As a result, four Li atoms can be stored by one formula unit of the P-Si
2
C
4
, corresponding to a theoretical gravimetric Li storage capacity of 1028.7 mAhg
−1
. The metallic electronic structures of the Li-adsorbed P-Li
x
Si
2
C
4
as well as very small Li migration energy barriers are beneficial for fast charge/discharge performance of the battery. The mechanism on the Li adsorption interaction on the P-Si
2
C
4
is discussed. These results demonstrate a novel strategy to design two-dimensional Si/C complex anode materials for high-performance Li-ion batteries.
Electronic supplementary material
The online version of this article (10.1186/s11671-019-3097-5) contains supplementary material, which is available to authorized users.
Asthma has been the most common chronic disease in children that places a major burden for affected people and their families.An integrated analysis of microarrays studies was performed to identify differentially expressed genes (DEGs) in childhood asthma compared with normal control. We also obtained the differentially methylated genes (DMGs) in childhood asthma according to GEO. The genes that were both differentially expressed and differentially methylated were identified. Functional annotation and protein-protein interaction network construction were performed to interpret biological functions of DEGs. We performed q-RT-PCR to verify the expression of selected DEGs.One DNA methylation and 3 gene expression datasets were obtained. Four hundred forty-one DEGs and 1209 DMGs in childhood asthma were identified. Among which, 16 genes were both differentially expressed and differentially methylated in childhood asthma. Natural killer cell mediated cytotoxicity pathway, Jak-STAT signaling pathway, and Wnt signaling pathway were 3 significantly enriched pathways in childhood asthma according to our KEGG enrichment analysis. The PPI network of top 20 up- and downregulated DEGs consisted of 822 nodes and 904 edges and 2 hub proteins (UBQLN4 and MID2) were identified. The expression of 8 DEGs (GZMB, FGFBP2, CLC, TBX21, ALOX15, IL12RB2, UBQLN4) was verified by qRT-PCR and only the expression of GZMB and FGFBP2 was inconsistent with our integrated analysis.Our finding was helpful to elucidate the underlying mechanism of childhood asthma and develop new potential diagnostic biomarker and provide clues for drug design.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.