We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls. Moreover, we evaluated the potential interplay between the studied miRNAs and fluoxetine in these patients after utilizing fluoxetine daily for 3 months. The study involved 60 consecutive LPE patients and 20 healthy age matched individuals as controls. The median miRNA16 was significantly higher in the controls (1.02) compared to the patients (0.31) (p < 0.001). Moreover, the median miRNA‐135a was significantly higher in the controls compared to the patients 1.02 and 0.35, p < 0.001, respectively. In addition, the median pre‐treatment miRNA16 in the responders was 0.29 that significantly increased to 0.66 (p < 0.001). The median pre‐treatment miRNA‐135a in the responders was 0.27 that significantly increased to 0.65 (p < 0.001). Furthermore, considering EXP(β) for the odds ratio evaluation, with a 95% degree of confidence, a 1 fold increase in pre‐treatment miRNA 135a fold change decreases the odds for being responsive to SSRI by 0.028. Meanwhile, there was non‐significant association between fluoxetine responsiveness and age, pre‐treatment miRNA 16, pre‐treatment PEDT and pre‐treatment IELT. The current study had shown that a lower pre‐treatment miRNA 135a was significantly associated with response to fluoxetine.

Priapism is considered as an unusual andrological emergency that requires urgent intervention. It is defined as prolonged penile erection (usually painful) for more than 4 hours not related to sexual excitation or stimulation. Several causes have been attributed to cause such condition including the use of psychotropic drugs as chlorpromazine. Only few case reports in literature have recorded priapism as a complication of administration of chlorpromazine, however most of them were due to overdose or prolonged administration for prolonged period or as an interaction with other drugs. Here, in this case report is about a 23 years old male presented to the emergency department with neglected priapism after administration of a single dose of chlorpromazine.