Until now, the world is still facing the COVID-19 pandemic caused by SARS-CoV-2. The number of deaths of COVID-19 patients in Indonesia is quite large when compared to other countries. Clinical manifestations, comorbidities, length of stay, and the mortality of COVID-19 vary widely in each study. This study analyzes clinical characteristics, comorbidities, length of stay, and mortality of COVID-19 patients in RSUD Cideres, Majalengka, West Java. This study is an observational study with total sampling and purposive sampling. Subjects were patients with nasal swabs confirmed SARS-CoV-2 and hospitalized at RSUD Cideres from January to July 2021. Clinical manifestations, comorbidities, length of stay, and mortality of COVID-19 patients aged ≥17 years old, were extracted from medical records. Results showed that the majority of 213 COVID-19 patients were age 41–60 years 114 (53.5%), female 114 (53.5%), with an upper respiratory tract in 207 (97.1%), and shortness of breath in 203 (95.3%) patients. 153 (71.8%) patients had a fever, while headache, diarrhea, and anosmia respectively 49 (23.0%), 19 (8.9%), and 10 (4.6%), respectively. Vital signs were the Glasgow Coma Scale (GCS) normal in 190 (89.2%) patients. Most of patients had respiration rate >20/min in 201 (94.3%), oxygen saturation <90% in 98 (46.0%), and chest x-rays: bronchopneumonia 134 (62.9%) and pneumonia 23 (10.7%). Comorbidities were hypertension, diabetes mellitus, and chronic heart failure in 74 (34.7%), 56 (26.2%), and 46 (11.7%) patients, respectively. The length of stay who died for 1–7 days (22 patients) and 8–14 days (9 patients); means almost all patients (29 of 32) died during the length of stay for 1–14 days. In conclusion, the majority of COVID-19 patients at RSUD Cideres are female, aged 41–60 years, had upper respiratory tract/shortness of breath, GCS normal, saturation oxygen <90%, chest x-rays: bronchopneumonia and pneumonia, comorbidities: hypertension, and length of stay for patients who died 1–7 days. KARAKTERISTIK KLINIS, KOMORBITAS, LAMA RAWAT, DAN MORTALITAS PASIEN COVID-19 DI RSUD CIDERES, MAJALENGKA, JAWA BARATHingga saat ini, dunia masih menghadapi pandemi COVID-19 yang disebabkan oleh SARS-CoV-2. Jumlah kematian pasien COVID-19 di Indonesia cukup besar jika dibanding dengan negara lain. Manifestasi klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 sangat bervariasi pada setiap penelitian. Tujuan penelitian ini menganalisis karakteristik klinis, komorbiditas, lama rawat, dan mortalitas pasien COVID-19 di RSUD Cideres, Majalengka, Jawa Barat. Penelitian ini adalah penelitian observasional dengan total sampling dan purposive sampling. Subjek adalah pasien dengan nasal swab terkonfirmasi SARS-CoV-2 dan dirawat di RSUD Cideres periode Januari hingga Juli 2021. Data manifestasi klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 usia ≥17 diambil dari rekam medik. Hasil menunjukkan bahwa mayoritas 213 pasien COVID-19 berusia 41–60 tahun 114 (53,5%) dan wanita 114 (53,5%) dengan keluhan saluran napas atas 207 (97,1%) dan napas pendek 203 (95,3%) pasien. 153 (71,8%) pasien mengalami demam, sedangkan sakit kepala, diare, dan anosmia masing-masing 49 (23,0%), 19 (8,9%), dan 10 (4,6%) pasien. Tanda vital Glasgow Coma Scale (GCS) normal pada 190 (89,2%) pasien. Kebanyakan pasien mempunyai frekuensi napas >20/menit pada 201 (94,3%) pasien, saturasi oksigen <90% pada 98 (46,0%) pasien, serta rontgen toraks: bronkopneumonia pada 134 (62,9%) pasien dan pneumonia pada 23 (10,7%) pasien. Komorbid adalah hipertensi, diabetes melitus, dan chronic heart failure pada 74 (34,7%), 56 (26,2%), dan 46 (11,7%) pasien berturut-turut. Lama rawat pasien yang meninggal 1–7 hari (22 pasien) dan 8–14 hari (9 pasien), berarti hampir semua pasien (29 dari 32) meninggal selama rawat 1–14 hari. Simpulan, mayoritas pasien COVID-19 di RSUD Cideres adalah wanita, berusia 41–60 tahun, keluhan saluran napas atas/napas pendek, GCS normal, rontgen toraks: bronkopneumonia dan pneumonia, komorbid: hipertensi, serta lama rawat pasien yang meninggal paling banyak 1–7 hari.
Introduction: Real time quantitative PCR is the gold standard for detection of SARS-CoV-2 which is specific, sensitive, and simple quantitative. The target of RT-qPCR is to assess the expression level of the SARS-CoV-2 gene through cycle threshold values (CT-value). The purpose of this study was to analyze the association of the level of SARS-CoV-2 gene expression and the severity of COVID-19 in patients hospitalized. Method: This research is an analytic observational study with cross sectional method. While the research sample was taken using a consecutive sampling technique from the Medical Records of Sumedang Hospital and Cideres Hospital, West Java, Indonesia from December 2020 to March 2021. Patient parameters include analysis of age, sex, comorbidity, and disease severity. The severity of the patient is classified based on complaints and oxygen saturation. The expression level of the SARS-CoV-2 N gene and E gene were assessed by calculating the relative quantification by comparing the expression of the E and N gene with the expression of the internal control gene by Livak formula (2-ΔΔCT Formula). Result: The Spearman correlation test showed that there was a relationship between the expression of SARS-CoV-2 genes E and N genes with the severity of COVID-19 patients (with r=0.374 and p<0.0001) and (with r=0.452 and p<0.0001). Conclusions: There is an correlation between the level of expression of genes E and gene N with the severity of patients.
<p><strong>ABSTRAK. </strong>Pabrik Moring Karya Bersama yang berlokasi di Lembursawah, adalah salah satu pabrik yang memproduksi makanan ringan yang terbuat dari tepung tapioka, tepung gandum, bawang putih, cabai merah, dan perasa lainnya. Selama masa ini, pabrik moring karya bersama memproduksi moring hanya berdasarkan intuisi pemilik pabrik, tanpa menggunakan perhitungan khusus, sehingga menghasilkan ketidakpastian keuntungan dan permintaan. Jika perusahaan dapat memprediksi jumlah permintaan penjualan perhari, maka biaya pengadaan dapat diminimalkan. Salah satu pendekatan yang dapat diambil untuk memperkirakan jumlah penjualan perhari adalah dengan menggunakan metode simulasi. Penelitian ini menggunakan Metode Simulasi <em>Monte Carlo</em> untuk menentukan permintaan perhari dan keuntungannya. Hasil penelitian membuktikan bahwa dari melakukan serangkaian uji coba enam hari permintaan, total penjualan mencapai 190 kg dengan permintaan harian rata-rata 32 kg dan memperoleh total keuntungan penjualan sebesar Rp3.600.000, dengan rata-rata keuntungan harian Rp600.000. Sehingga menjadi gambaran pemilik pabrik untuk penjualan pada hari berikutnya (hari yang akan datang).</p><p><strong>Kata kunci</strong><strong>:</strong> Simulasi<em> Monte Carlo</em>, Permintaan, Keuntungan</p><p> </p><p><strong><em>ABSTRACT. </em></strong><em>The Moring Karya Bersama factory, located in Lembursawah, is one of the factories that produce snacks made from tapioca flour, wheat flour, garlic, red chili, and other flavorings. During this time, the moring plant produces moring based only on the factory owner's intuition, without using special calculations, which results in uncertainty of profit and demand. If the company can predict the number of sales requests per day, procurement costs can be minimized. One approach that can be taken to estimate the number of sales per day is to use a simulation method. This study uses the Monte Carlo Simulation Method to determine daily requests and benefits. The results of the research prove that from conducting a series of six-day demand trials, total sales reached 190 kg with an average daily demand of 32 kg and obtained a total sales profit of Rp3,600,000, with an average daily profit of Rp600,000. factory for sale the next day (days to come).</em></p><strong><em>Keywords: </em></strong><em>Monte Carlo Simulation, Demand, Benefits</em>
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