Introduction: Dermatitis herpetiformis or also known as Duhring's Disease or gluten rash is an autoimmune vesicobulose disease, this disease is not related to dermatitis, nor is it caused by the herpes virus, but a specific and recurrent chronic skin condition associated with celiac disease and gluten-sensitive enteropathy. The main predisposing factor is genetics, this is related to Human Leukocyte Antigens (HLAs) DQ2 and DQ8. Dermatitis herpetiformis can affect any age but appears more often for the first time in young adults between the ages of 30 and 40, more often in men than in women, where the lesions in men are common in the mouth and genitalia.
Discussion:The main lesions are erythematous papules, plaques, urticaria, or most commonly vesicles, of which large bullae rarely occur. The lesions seen in people with dermatitis herpetiformis may be crusted and may not show the main lesion. On physical examination, excoriation and erosion are common. The distribution of lesions in dermatitis herpetiformis is symmetrical with a frequent predilection of the extensor surfaces of the forearms, elbows, shoulders, knees, buttocks and back. The main therapeutic management of dermatitis herpetiformis is a gluten-free diet. Adherence to a strict gluten-free diet resulted in resolution of symptoms of dermatitis herpetiformis and a positive development of intestinal pathology. Despite implementing a non-strict gluten-free diet, the accumulation of IgA in the dermoepidermal junction in dermatitis herpetiformis patients will slowly disappear and may take several years to completely disappear.
Conclusion:The management of patients with dermatitis herpetiformis should be a team consisting of a dermatologist, a gastroenterologist and a nutritionist. Patients require follow-up to monitor long-term medication use and control recurrence of symptoms. Regular visits will facilitate screening and early detection of autoimmune conditions or neoplasms that may be associated with dermatitis herpetiformis and to obtain referral therapy for patients experiencing them.
Background: Lichenoid reaction as the result of hypersensitivity from drug might be had similir clinical appearance to idiopathic lichen planus. Lichenoid drug reaction is termed as a condition of the oral cavity having an identifiable etiology, which is clinically and histologically similar to oral lichen planus and also manifest on genital. A number of drugs have been described as a causative factor of those reactive lesions. Objectives : The aim of this study is to finding mechanism of oral-genital lichenoid reaction caused by drugs. Problem Statement: Potential Pathway of Oral-genital lichenoid reaction caused by drugs. Discussion: Oral lichenoid lesions could be impact from medication and contact antigenic reaction. Clinical condition these two look similar to oral lichen planus, also its pathology. Studies of LDR caused by angiotensin-converting enzyme (ACE) inhibitors, antimalaria, antituberculosis, antitumor and non-steroidal anti-inflammatory drugs (NSAIDs) have been found. Conclusion: OLR is a disease condition with definite identifiable aetiology. Cell-mediated immune dysregulation has been associated with pathogenesis, explaining oral and genital manifestation.
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