Ovarian carcinoma is the common cause of most death cases in female genital malignancy. Ovarian carcinoma is considered as one of the carcinomas that can evoke immune responses. One of the immune responses is characterized by lymphocyte infiltration of a tumor (tumor infiltrating lymphocytes). This study aims to determine the association of density of tumor infiltrating lymphocytes (TILs) with CD8+ tumor infiltrating lymphocytes and histopathologic subtypes of ovarian carcinoma. This study was a cross-sectional study. Samples were taken based on five main histopathologic subtypes of ovarian carcinoma from January 1, 2015, until December 31, 2017, comprising 50 cases. All preparations were stained with CD8 monoclonal antibody. The density of intratumoral and stromal TILs was subsequently evaluated on histopathologic preparations and immunohistochemical examination. The association between the density of TILs, CD8+ tumor-infiltrating lymphocytes and histopathologic subtypes of ovarian carcinoma was evaluated using Spearman, Kruskal-Wallis, and Mann-Whitney test. The density of TILs and intratumoral CD8+ TILs were associated with histopathologic subtypes, especially high-grade serous carcinoma that had a different density value compared to other histopathologic subtypes. In addition, the density of TIL and intratumoral CD8+ TIL had a meaningful association with histopathologic subtypes of ovarian carcinoma.
BackgroundPapillary thyroid carcinoma is the most common subtype among thyroid cancers. The interaction between cancer cells and tumormicroenvironment plays roles in cancer proliferation and invasiveness. One of important components of tumor microenvironmentthat could stimulate tumor proliferation and invasiveness is activated fibroblast, known as carcinoma associated fibroblasts (CAFs).The aim of this research is to analysed FAP expression is associated with clinicopathologic characteristics.MethodsThis retrospective descriptive observational study with serial cases design was conducted in 40 samples of the paraffin blocks oftissues registered in Department of Anantomical Pathology Faculty of Medicine University of Sriwijaya/Dr. Moh. Hoesin PalembangHospital from January 1st, 2017 to October 31st, 2019. All samples were immunostained with FAP antibody. The expressions of FAPwere evaluated in accordance with the results of the previous study. Statistical test was performed by using Chi-square andSpearman-rho statistical test. Statistical analysis was performed by using SPSS version 23.0.ResultsOur data indicated that patients who were ≥45 years old (21 cases; 52.5%), women (31 cases; 77.5%) suffered from this cancer themost. The stromal type found in ten classic, follicular, solid and columnar variance were pauci (25 cases; 62.6%), desmoplastic (8cases;20%), sclerosis (5 cases; 12.5%) and inflammatory (2 cases; 5%). The expression of FAP in tumor stroma has a significantcorrelation with histopathology subtypes (p=0.028) and stromal type (p=0.000).ConclusionFAP was expressed in tumor epithelial cells and fibroblast stromal tumour of papillary thyroid carcinoma. FAP expression in stromaltumor between histopathologic subtype and stromal type showed significant correlation
A B S T R A C TBackground Prostate cancer is the most common cancer in men worldwide and rankssecond in the Laboratory of Anatomical Pathology, Dr. Mohammad Hoesin with thehighest incidence, especially at the age of more than 60 years. Factors that play a roleas a prognostic factor and therapy in prostate carcinoma, including VEGF. The roleof VEGF expression in prostate carcinoma as a prognostic and histopathological factorwhich is an important predictor for the progression of prostate carcinoma. This studyaims to determine the relationship between VEGF expression and Gleason score inprostate carcinoma. Method This study was a cross-sectional observational study.Thirty samples diagnosed with prostate adenocarcinoma were derived from the resultsof the tranurethral resection of the prostate (TRUP) and prostatectomy. Samples weretaken from the archives in the Anatomic Pathology section of Dr. Mohammad HoesinPalembang (period January 1, 2011 to December 31, 2013. Then the sample wasstained with VEGF antibody, identified and analyzed the VEGF relationship with theGleason.z score. Results The positivity of VEGF expression in prostateadenocarcinoma tended to be more prevalent in the Gleason score group ≥ 7 (43.3%)than in the Gleason score group <(10%). There was no significant relationship betweenVEGF expression and high Gleason score (p> 0.05). Conclusion There was nosignificant relationship between VEGF expression and Gleason score in prostateadenocarcinoma
Kejadian kanker serviks di Indonesia masih menduduki peringkat kedua penyebab kematian terbanyak pada wanita. Lesi prakanker sebagai lesi prekursor dapat dideteksi secara dini dengan cara pemeriksaan sitologi Pap Smear. Pemeriksaan Pap Smear diindikasikan bagi setiap wanita yang telah menikah dan dilakukan secara periodik. Jika ditemukan lesi prakanker maka diperlukan penanganan medis yang tepat sehingga lesi tidak berlanjut menjadi kanker serviks. Metode pelaksanaan kegiatan melalui Penyuluhan dan Pemeriksaan Pap Smear dengan sasaran semua wanita yang telah menikah. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat tentang pentingnya pemeriksaan dini kanker serviks dan mendeteksi secara dini lesi prakanker serviks dengan pemeriksaan Pap Smear. Penilaian untuk mengetahui tingkat pengetahuan peserta dilakukan melalui pre-test dan post-tes. Kegiatan penyuluhan dan pemeriksaan diadakan sebanyak 4 kali dalam bulan September-Oktober 2021 di dua lokasi yaitu Puskesmas Gandus dan praktek bidan Hj. Nani. Pengabdian masyarakat ini berhasil menghimpun peserta penyuluhan sebanyak 130 orang. Hasil pretest dan post peserta penyuluhan menunjukkan peningkatan pengetahuan para peserta tentang pentingnya deteksi dini kanker serviks dari nilai rata-rata 75,57 menjadi 89,28. Dari hasil diagnostik Pap Smear diperoleh bahwa peserta paling banyak menderita servitis kronik non spesifik yang termasuk ke dalam Negative for Intraepithelial Lesion or Malignancy (NILM). Penyuluhan dan deteksi dini ini sangat efektif dalam upaya pencegahan kanker serviks.
Objective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisher’s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one.
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