Oral administration of medicine faces physiological constraints imposed by the gastrointestinal tract (GIT) and simultaneously causes irritation to GI mucosa, which motivates us to pursue the innovation of a GI drug delivery system. Inspired by the mucosa-nutrient functions of Zinc element and smectite clay, a montmorillonite (MMT)enveloped zeolitic imidazolate framework (M-ZIF-8) is developed in a successive one-pot fabrication of ZIF-8 encapsulated medicine, and followed MMT coating to yield a core− shell nanoplatform for GI drug delivery. ZIF-8 encapsulated medicines can maintain their intrinsic structure, and MMT layer potentiates mucous-adhesion and optimizes medicine release. Validated in gastritis and colitis models, M-ZIF-8 not only achieves efficient GI delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) for inflammation inhibition, but also reduces the NSAIDs-induced GI irritation, promoting mucosal healing in GIT. Coupled with the facile construction and biocompatibility, M-ZIF-8 shows a significant advancement in GI drug delivery.

Selective preparation of unsaturated alcohols via the hydrogenation of CO in α,β-unsaturated aldehydes is a challenging reaction. In this work, a nanoscale material Pt/UiO-66 catalyst with homogenously dispersed Pt nanoparticles encapsulated in UiO-66 was prepared. Its performance for the selective formation of unsaturated alcohols from unsaturated aldehydes with molecular H2 and via the catalytic transfer hydrogenation (CTH) was compared. It was found that Pt/UiO-66 was more selective and efficient for the hydrogenation of the CO bond to alcohol when isopropanol was utilized as hydrogen donors instead of molecular H2. The selectivity of unsaturated alcohols reached 94.6% at a 90.5% conversion of unsaturated aldehydes at 150 °C. At the same time, the utilization of isopropanol as hydrogen donors reached 92.6%, and a turnover frequency of 4071 h–1 was achieved. The CTH reaction mechanism over Pt/UiO-66 was suggested based on the results of several control experiments.