Montmorillonite-Enveloped Zeolitic Imidazolate Framework as a Nourishing Oral Nano-Platform for Gastrointestinal Drug Delivery

Zhao, Huaiyuan; Ye, Hengshu; Zhou, Jun; Tang, Guping; Hou, Zhenshan; Bai, Hongzhen

doi:10.1021/acsami.0c15494

Cited by 36 publications

(17 citation statements)

References 41 publications

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“…Surgical resection is the major treatment strategy for various cancers. However, the very high local recurrence rate of cancer after surgical resection remains a clinically fatal problem [ 46 – 48 ]. Inspired by the in vitro magnetic hyperthermia effect and controlled drug release of MCG DOX , MCG DOX was expected to effectively inhibit locoregional tumor recurrence after resection.…”

Section: Resultsmentioning

confidence: 99%

Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma

Chen

Song

et al. 2022

J Nanobiotechnol

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Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.

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Section: Resultsmentioning

confidence: 99%

Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma

Chen

Song

et al. 2022

J Nanobiotechnol

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“…They have various functions, such as small size, large specific surface area, strong adhesion and targeting, easy access to human cells to achieve high drug efficacy, elimination of biological barriers of drug action, maintenance of drug stability, various functional modifications, and sustained or controlled release of drugs. Compared with conventional drug formulations, oral nano-drug delivery systems have significant advantages in terms of improving bioavailability, extended drug half-life, and targeted delivery [ 80 , 81 , 82 ]. Therefore, oral delivery nanosystems are widely used in the development of oral formulations of insulin.…”

Section: Oral Insulin Delivery Nanosystemsmentioning

confidence: 99%

Versatile Oral Insulin Delivery Nanosystems: From Materials to Nanostructures

Wang

Ren

et al. 2022

IJMS

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Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading to failure of blood glucose regulation. Diabetes patients usually need frequent insulin injections to maintain normal blood glucose levels, which is a painful administration manner. Long-term drug injection brings great physical and psychological burden to diabetic patients. In order to improve the adaptability of patients to use insulin and reduce the pain caused by injection, the development of oral insulin formulations is currently a hot and difficult topic in the field of medicine and pharmacy. Thus, oral insulin delivery is a promising and convenient administration method to relieve the patients. However, insulin as a peptide drug is prone to be degraded by digestive enzymes. In addition, insulin has strong hydrophilicity and large molecular weight and extremely low oral bioavailability. To solve these problems in clinical practice, the oral insulin delivery nanosystems were designed and constructed by rational combination of various nanomaterials and nanotechnology. Such oral nanosystems have the advantages of strong adaptability, small size, convenient processing, long-lasting pharmaceutical activity, and drug controlled-release, so it can effectively improve the oral bioavailability and efficacy of insulin. This review summarizes the basic principles and recent progress in oral delivery nanosystems for insulin, including physiological absorption barrier of oral insulin and the development of materials to nanostructures for oral insulin delivery nanosystems.

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“…Inorganic carriers such as layered double hydroxides (LDHs) [28,29] and montmorillonite (MMT) [30][31][32][33][34] clays have been used for various biomedical applications [35], thanks to their excellent bio-compatibility, easy modification, and encapsulation capability for various therapeutic agents [36]. In particular, MMT has been approved by the FDA as a diluting agent for oral administration [36,37].…”

Section: Powder X-ray Diffraction (Pxrd) Analysismentioning

confidence: 99%

Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

Piao

Rejinold

et al. 2021

Polymers

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Niclosamide (NIC), a conventional anthelmintic agent, is emerging as a repurposed drug for COVID-19 treatment. However, the clinical efficacy is very limited due to its low oral bioavailability resulting from its poor aqueous solubility. In the present study, a new hybrid drug delivery system made of NIC, montmorillonite (MMT), and Tween 60 is proposed to overcome this obstacle. At first, NIC molecules were immobilized into the interlayer space of cationic clay, MMT, to form NIC–MMT hybrids, which could enhance the solubility of NIC, and then the polymer surfactant, Tween 60, was further coated on the external surface of NIC–MMT to improve the release rate and the solubility of NIC and eventually the bioavailability under gastrointestinal condition when orally administered. Finally, we have performed an in vivo pharmacokinetic study to compare the oral bioavailability of NIC for the Tween 60-coated NIC–MMT hybrid with Yomesan®, which is a commercially available NIC. Exceptionally, the Tween 60-coated NIC–MMT hybrid showed higher systemic exposure of NIC than Yomesan®. Therefore, the present NIC–MMT–Tween 60 hybrid can be a potent NIC drug formulation with enhanced solubility and bioavailability in vivo for treating Covid-19.

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Montmorillonite-Enveloped Zeolitic Imidazolate Framework as a Nourishing Oral Nano-Platform for Gastrointestinal Drug Delivery

Cited by 36 publications

References 41 publications

Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma

Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma

Versatile Oral Insulin Delivery Nanosystems: From Materials to Nanostructures

Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

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