Stress is an adaptive response to a situation that is perceived to challenge or threaten a person's health. Work stress in nurses is one of the problems in the management of human resources at the hospital. This study aims to determine the relationship between job stress with job burnout in nurses Regional General Hospital (Hospital) Deli Serdang Lubukpakam. The method used in this study using a type of analytical research with cross sectional design. Gamma test results between job stress with job burnout in nurses obtained significant values (p) obtained was 0,016. To view the results of significant statistical calculations used the limit of significance α = 0.05. Based on the above values indicate significant p value <0.05 which means that the hypothesis there is a relationship between job stress and fatigue in nurses working at the General Hospital (Hospital) Deli Serdang Lubukpakam accepted. There was a significant relationship between work stress fatigue. The need for provision of extension or improvement of knowledge about the factors that can lead to work stress, work fatigue and how to treat the condition.
Background: Breast carcinoma is a malignancy that occurs from breast cells that grow and continue to proliferate uncontrollably. S100A4 has the potential to increase tumor metastasis in preexisting tumorigenic breast cancer. S100A4 protein expression level is associated with poor prognosis in breast cancer. Objective: To analyze the relationship between immunohistochemical expression of S100A4 with histopathological grading and molecular subtypes in invasive breast carcinoma of no special type. Methods: Formalin-fixed tissue paraffin blocks from 42 invasive breast carcinomas of no special type were used as research samples and S100A4 immunohistochemical staining was assessed. The relationship between S100A4 expression and histopathological grading and molecular subtypes was analyzed by statistical tests using the SPSS program. Results: Based on the histopathological grade, grade 3 was 18 samples (42.9%), grade 1 was 10 samples (23.8%), and grade 1I was 14 samples (33.3%). Based on the molecular subtype, Luminal A as many as 16 samples (38.1%), HER2-enriched as many as 12 samples (28.6%), Luminal B as many as 12 samples (28.6%), and Triple-negative as many as 2 samples (4.8% ). Immunohistochemical expression of S100A4 was positive in as many as 33 samples (78.6%). Conclusion: There is a significant relationship between the immunohistochemical expression of S100A4, either with histologic grading or with molecular subtypes in Invasive Breast Carcinoma of No Special Type (NST) p (0.034) < 0.05 and p (0.039) < 0.05
Stress is an adaptive response to a situation that is perceived to challenge or threaten a person's health. Work stress in nurses is one of the problems in the management of human resources at the hospital. This study aims to determine the relationship between job stress with job burnout in nurses Regional General Hospital (Hospital) Deli Serdang Lubukpakam. The method used in this study using a type of analytical research with cross sectional design. Gamma test results between job stress with job burnout in nurses obtained significant values (p) obtained was 0,016. To view the results of significant statistical calculations used the limit of significance α = 0.05. Based on the above values indicate significant p value <0.05 which means that the hypothesis there is a relationship between job stress and fatigue in nurses working at the General Hospital (Hospital) Deli Serdang Lubukpakam accepted. There was a significant relationship between work stress fatigue. The need for provision of extension or improvement of knowledge about the factors that can lead to work stress, work fatigue and how to treat the condition.
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