BLOOD GROUPS AND DISEASE BDRmH MEDICAL JOURNAL frequency of CDe/cDE and MN people may be found, unless care is taken to study only those who have not been transfused. Previous transfusion may possibly be the explanation of the high CDe/cDE frequency found in duodenal ulcer by Buckwalter and Tweed (1962). We are grateful to the Research Committee of the United Liverpool Hospitals under the chairmanship of Lord Cohen of Birkenhead, to the Medical Research Council, and to the Nuffield Foundation for generous grants towards this work. AIDDNDUM.-Since writing this paper we have Rhgrouped (1) a series of 139 duodenal ulcer patients while they were in hospital, (2) a series of 111 duodenal ulcer patients who have not been in hospital for at least a year, and (3) a control series of 256. We found the CDeIcDE frequencies to be 26.62%, 16.21%, and 12.89% respectively. After the blood groupings had been carried out we studied the case sheets of the first series and found that approximately 50% of the patients had had a recent previous blood transfusion. Our figures, therefore, are in agreement with the theoretical frequencies given in this paper and are further evidence of previous recent blood transfusion being able to account for Buckwalter and Tweed's (1962) finding of a high CDe/cDE frequency in duodenal ulcer. REFERENCES
The average number of treatments required in the satisfactory cases was 4.5.Forty cases of monilial infection in pregnancy treated with the same preparation were all regarded as cured.We thank Messrs. Camden Chemical Co. for liberal supplies of this compound, which is marketed under the name of " pruvagol."
SummaryFifty-one cases of small acute corneal ulcers were examined, and healing time ascertained by instillation of sodium fluorescein under standard arbitrary conditions.Approximately half the patients received 1.5 g. of ascorbic acid daily; the remainder were given control tablets.Deep ulcers healed significantly more slowly than superficial ulcers.The administration of large doses of ascorbic acid had no significant effect upon the healing time of superficial ulcers, but significantly accelerated the healing of deep ulcers.It is suggested that there may be a localized area around the site of regenerating corneal collagen where the ascorbic acid level falls below the opti.num for rapid healing. Raising the general ascorbic acid level with massive doses increases the local rate of replacement.Pyorrhoea occurred significantly more frequently in patients with corneal ulcers than in others with non-infective eye complaints.
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