Monosodium glutamate (MSG) has been traditionally used as a flavor enhancer and is added to many foods. The chronic consumption of MSG has been suggested as causing toxicity, inflammation, obesity, type 2 diabetes, and pre‐malignant changes. The use of medicinal plants and their products, such as ginger, against the effects of MSG has been suggested to have a protective effect. To evaluate the anti‐inflammatory activity of ginger against the effects of MSG, we conducted a serial inflammatory analysis of MSG‐ and ginger‐treated rats, focusing particularly on liver pathology. The consumption of ginger as an unconventional therapy against the effects of MSG resulted in significant anti‐inflammatory activity. We found that it was possible to diagnose MSG‐associated inflammatory pathogenesis using inflammatory mediators. Ginger consumption produced protective effects on health, minimized adverse effects, and may be applicable for food development and the treatment of many inflammatory diseases. Practical applications The chronic administration of monosodium glutamate (MSG) as a flavor enhancer has been suggested to produce toxicity, inflammation, and pre‐malignant changes in organs. Ginger has protective effects, with potent anti‐inflammatory and anti‐fibrotic activity against MSG administration. This study is the first to report that ginger modulated the inflammatory and fibrotic effects of MSG and improved immunological indices reflecting the involvement of inflammatory and fibrotic markers and polysaccharide content in the activation of macrophages. These findings support the further use of ginger as a supplement for food enhancement and as an anti‐fibrotic, anti‐inflammatory, and therapeutic agent in pharmaceutical therapies against autoimmune and inflammatory diseases, such as rheumatoid arthritis, lupus, and ulcerative colitis, as well as MSG‐associated inflammatory diseases.
Background: Monosodium glutamate (MSG) usage has been increased in the industry year after year reflecting its crescent use in the food industry. MSG toxicity is specific to the tissue in the body. Herbal drugs provide a managing role for several hepatic disorders so it is critical to find an effective and preventive agent to manage various hepatic insults.Objective: This experimental study aimed to examine the possible protective effect of ginger extract against injury induced by MSG as a therapeutic agent in pharmaceutical therapies. Materials and methods: Four groups of rats were divided and obtained treatment periods, after that they conducted serial histological and histochemical changes in control, MSG-and ginger-treated rats, focusing particularly on liver pathology. Results: MSG exhibited histological and histochemical changes in the liver. Such alterations induced hepatopathology, involving a return to a somewhat normal condition-ginger treatment. Conclusions: Ginger as herbal supplementations speed up the healing progression of hepatotoxicity. This study reports the effect of ginger exerts anti-toxicity and anti-fibrotic potentials.
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