SIntroduction: Hyperthyroidism is characterized by increased synthesis and release of thyroid hormones by the thyroid gland. Thyrotoxicosis refers to the clinical syndrome resulting from excessive circulating thyroid hormones, secondary to hyperthyroidism or due to other causes. This article describes evidence-based guidelines for the clinical management of thyrotoxicosis. Objective: This consensus, developed by Brazilian experts and sponsored by the Department of Thyroid Brazilian Society of Endocrinology and Metabolism, aims to address the management, diagnosis and treatment of patients with thyrotoxicosis, according to the most recent evidence from the literature and appropriate for the clinical reality of Brazil. Materials and methods: After structuring clinical questions, search for evidence was made available in the literature, initially in the database Medline, PubMed and Embase databases and subsequently in SciELO -Lilacs. The strength of evidence was evaluated by Oxford classification system was established from the study design used, considering the best available evidence for each question. Results: We have defined 13 questions about the initial clinical approach for the diagnosis and treatment that resulted in 53 recommendations, including the etiology, treatment with antithyroid drugs, radioactive iodine and surgery. We also addressed hyperthyroidism in children, teenagers or pregnant patients, and management of hyperthyroidism in patients with Graves' ophthalmopathy and various other causes of thyrotoxicosis. Conclusions: The clinical diagnosis of hyperthyroidism usually offers no difficulty and should be made with measurements of serum TSH and thyroid hormones. The treatment can be performed with antithyroid drugs, surgery or administration of radioactive iodine according to the etiology of thyrotoxicosis, local availability of methods and preferences of the attending physician and patient. Arq Bras Endocrinol

The prevalence of CH was within the previously reported range of 1:3000-4000. Ectopy was the most common etiology. Clinical analysis revealed distinct hormonal patterns in TH subgroup when compared with other variants of TD, with genetic abnormalities identified only in few cases in the TSH-R, PAX8, and NKX2.5 genes.

Some potential deficiencies in the diagnosis and management of DON and hyperthyroidism were observed in our survey, highlighting the need for improvement in specialist education and the quality of care offered to patients with GO in Latin America.

<strong style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman', serif;">Introdução</span></strong><span style="text-align: justify; font-size: 10pt; font-family: 'Times New Roman', serif;">: Após a implantação do Programa Nacional de Atenção à Saúde Auditiva (PNASA), em 2004, houve incontestáveis avanços na assistência ao deficiente auditivo. Porém, existem divergências na execução desse programa que dificultam o seu progresso e limitam o acesso à Saúde Auditiva. Tais evidências ilustram a necessidade da criação de uma rotina para avaliá-lo a fim de reorientar e monitorar as práticas dos atores envolvidos. <strong>Objetivo:</strong> Analisar os progressos e entraves da Política de Saúde Auditiva do país na atual conjuntura brasileira. <strong>Metodologia</strong>: Trata-se de um estudo exploratório com abordagem quantitativa realizado no período de junho a agosto de 2013, através da análise de dados secundários (SAI/SUS e CNES). <strong>Conclusão</strong>: Observou-se que a implantação do PNASA não é uniforme no país. A disparidade está evidenciada na cobertura nacional e distribuição local desse serviço, o que denota um imenso contingente de deficientes auditivos não contemplados com a assistência à Saúde Auditiva, ferindo os princípios de integralidade e universalidade do SUS.</span>