Cutaneous angiosarcoma is a rare malignant tumor showing blood or lymphatic vessel differentiation, corresponding to < 2% of all sarcomas. It preferably affects elderly, with predilection for the head and neck. Diagnosis is frequently late due to the early interpretation by the patient as a benign lesion similar to ecchymosis, which explains its aggressiveness with high metastasis and recurrence rates. We report the case of an elderly man whose histopathologic diagnosis confirmed the clinical suspicion of cutaneous angiosarcoma.
Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the
skin. Infections caused by members of the herpesviridae family have
been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not
for PF. The present study aimed to investigate the presence of Human
herpesvirus (types 1, 2, 3) in corticosteroid refractory skin
lesions from a patient with PF, by a Polymerase chain reaction (PCR) assay. The
sample collected from cutaneous blisters has tested positive for herpes
simplex virus type 1 (HSV1) after sequence analysis of the amplified
viral genomic segment. The study concluded that when PF patients present
corticosteroid or immunosuppressants refractory lesions, herpetic infection should be
considered.
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